Jul 3, 2023 · Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its...

Dec 25, 2024 · TXNIP (Thioredoxin Interacting Protein) is a Protein Coding gene. Diseases associated with TXNIP include Leukostasis and Hyperglycemia . Among its related pathways are Inflammasomes and Gene expression (Transcription) .

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. [5] [6]

In this review, we summarized the main structure, binding proteins, pathways, and the role of TXNIP in diseases, aiming to explore the double-edged sword role of TXNIP, and expect it to be helpful for future treatment using TXNIP as a therapeutic target.

Oct 4, 2023 · Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent...

Mar 9, 2021 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is …

TXNIP regulates glucose homeostasis as signal complex. The TRX/TXNIP signal complex, redoxisome, is the basis of TXNIP regulation of the reduction–oxidation (redox) response. TXNIP has been known to bind NOD-like receptor protein 3 (NLRP3) and activate the inflammasome.

Feb 8, 2025 · TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis. Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. TXNIP Promotes Human NK Cell Development but Is Dispensable for NK Cell Functionality.

Jul 17, 2022 · Thioredoxin-interacting protein (TXNIP), also known as Thioredoxin-binding protein-2 or Vitamin D3 up-regulated protein-1, was originally identified as an endogenous antagonist of thioredoxin (Trx), a key regulator in cellular redox equilibrium [3].

Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its antioxidant function and expression.