Mucolipin-1 (ML1) also known as TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) is a protein that in humans is encoded by the MCOLN1 gene. [5] It is a member of the small family of the TRPML channels, a …

Oct 11, 2017 · Transient receptor potential mucolipin 1 (TRPML1) is a Ca 2+ -releasing cation channel that mediates the calcium signalling and homeostasis of lysosomes. Mutations in TRPML1 lead to...

Dec 10, 2019 · The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate autophagic genes by inducing the nuclear...

The first member of the mammalian mucolipin TRP channel subfamily (TRPML1) is a cation-permeable channel that is predominantly localized on the membranes of late endosomes and lysosomes (LELs) in all mammalian cell types.

TRPML1 channel-mediated lysosome Ca 2+ bursts activate CICR that is an important regulatory mechanism of vasoconstriction. Furthermore, TRPML1 channel regulates various cellular activities, including autophagy, lysosomal exocytosis, …

TRPML1 is the most extensively studied member of a small family of genes that also includes TRPML2 and TRPML3, and it has been found to participate in vesicular trafficking, lipid and ion homeostasis, and autophagy.

Jul 24, 2019 · Here, we showed that in motor neuronal cells TRPML1 as well as the lysosomal protein LAMP1 co-localized with ER. In addition, TRPML1 co-immunoprecipitated with the ER Ca2+ sensor STIM1.

Jan 1, 2018 · Mutations in human TRPML1 gene cause mucolipidosis type IV, a severe neurological lysosomal storage disorder. In this review, we provide an overview of the most recent studies aimed to characterize the role of TRPML1 on lysosomal function in health and disease.

Transient receptor potential mucolipin 1 (TRPML1) is a Ca 2+-releasing cation channel that mediates the calcium signalling and homeostasis of lysosomes. Mutations in TRPML1 lead to mucolipidosis type IV, a severe lysosomal storage disorder.

Feb 8, 2024 · Transient receptor potential mucolipin 1 (TRPML1) is a major non-selective cation-permeable ion channel that localizes to the membranes of late endosomes and lysosomes. TRPML1 is proposed to mediate Ca 2+ efflux from the lysosomal lumen to the cytosol, coordinating lysosomal exocytosis, lysosomal biogenesis, autophagy, and the fusion of late ...