TRAF6 Osteoclast - Search

Open links in new tab

Copilot Answer
PubMed
https://pubmed.ncbi.nlm.nih.gov
Osteoclast differentiation independent of the TRANCE-RANK …
Genetic deletion of TRANCE or its receptor, receptor activator of nuclear factor kappaB (RANK), results in severely osteopetrotic mice with no osteoclasts in their bones. TNF receptor-associated factor (TRAF) 6 is a key signaling adaptor for RANK, and its deficiency leads to similar osteopetrosis.
TRAF6 Ubiquitin Ligase is Essential for RANKL Signaling and Osteoclast ...
Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-κB (RANK), plays an essential role i…
nih.gov
TRAIL inhibits RANK signaling and suppresses osteoclast ... - Nature
Recent evidence indicated that TNF-α-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation via a TRAF6-dependent signaling pathway; b…
Nature
What does TRAF6 stand for?
The publisher's final edited version of this article is available at Biochem Biophys Res Commun Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-κB (RANK), plays an essential role in governing the formation of multi-nucleated osteoclasts.
ncbi.nlm.nih.gov
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast ...
Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-kappaB (RANK), plays an essential …
PubMed

nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
TRAF6 Ubiquitin Ligase is Essential for RANKL Signaling and …
Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-κB (RANK), plays an essential role in governing the formation of multi …
Images of Traf6 osteoclast

bing.com › images
frontiersin.org
Frontiers | Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 ...
researchgate.net
Schematic representation of osteoclast activation by RANKL, IL-l, and ...
researchgate.net
| Signal passways in the process of osteoclastogenesis under the ...
researchgate.net
HSP90 participates in osteoclast differentiation through TRAF6/NFATc1 ...
researchgate.net
(A) Expression of the osteoclast-specific genes including NFATc1 ...
See all
See all images
Explore
Osteoclast Formation
Osteoclast Diagram
Osteoclast Function
Osteoclast Morphology
Osteoclast Cell
Bone Osteoblasts Osteoclasts
Osteoclast Differentiation
Osteoclastogenesis
Osteoclast Marker
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
CHIP Regulates Osteoclast Formation through Promoting TRAF6 …
In this study, we found that deletion of the Chip gene leads to osteopenic phenotype and increased osteoclast formation. We further found that TRAF6, as a novel substrate of CHIP, is …
Nature
https://www.nature.com › articles
TRAIL inhibits RANK signaling and suppresses osteoclast ... - Nature
Jan 28, 2019 · Recent evidence indicated that TNF-α-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation via a TRAF6-dependent signaling pathway; but …
- Author: Hsiu-Jung Liao, Hwei-Fang Tsai, Chien-Sheng Wu, I-Tsu Chyuan, Ping-Ning Hsu
- Publish Year: 2019
ScienceDirect
https://www.sciencedirect.com › science › article › pii
A RANK/TRAF6-dependent Signal Transduction Pathway Is …
Nov 15, 2002 · The defects in osteoclast cytoskeletal organization that we have defined with the RANK/TRAF6 binding mutant may affect ruffled border assembly, cell migration, exocytosis, or …
- Author: Allison P. Armstrong, Mark E. Tometsko, Moira Glaccum, Claire L. Sutherland, David Cosman, William C...
- Publish Year: 2002
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
RANK-mediated amplification of TRAF6 signaling leads to NFATc1 ...
Establishment of an ex vivo assay system for osteoclast formation induced by a chimeric receptor of CD40 and RANK. (A) Schematic diagram of the chimeric receptor of human CD40 and …
People also ask
What is the role of TRAF6 in osteoporosis?
TRAF6 is the critical RANK-associated signaling molecule regulating osteoclast differentiation and activity. TRAF6-knockout mice displayed a defect in NF-κB signaling and consequently developed osteopetrosis, indicating the essential role of TRAF6 in osteoclast function 7, 33.
TRAIL inhibits RANK signaling and suppresses osteoclast ... - Nature
nature.com
Does TRAF6 inhibit osteoclast differentiation?
TRAIL-induced osteoclast differentiation was significantly inhibited by treatment with TRAF-6 siRNA and TRAF6 decoy peptides in both human monocytes and murine RAW264.7 macrophage cell lines, as evaluated in terms of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and bone resorption activity.
TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apop…
ncbi.nlm.nih.gov
What does TRAF6 stand for?
The publisher's final edited version of this article is available at Biochem Biophys Res Commun Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-κB (RANK), plays an essential role in governing the formation of multi-nucleated osteoclasts.
TRAF6 Ubiquitin Ligase is Essential for RANKL Signaling and Osteoclast
ncbi.nlm.nih.gov
Is TRAF6 ubiquitin ligase essential for RANKL signaling and osteoclast differentiation?
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Biochem Biophys Res Commun. 2007;359:1049. [ PMC free article] [ PubMed] [ Google Scholar]
TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apop…
ncbi.nlm.nih.gov
Does TRAF6 inhibitory peptide inhibit RANKL-mediated osteoclast differentiation in raw macrophages?
The TRAF6 inhibitory peptide, T6PD (DRQIKIWFQNRRMKWKKRKIPTEDEY; IMGENEX, San Diego, CA), which was shown to specifically target TRAF6 and inhibit RANKL-mediated signaling and osteoclast differentiation , was used to examine its effects on TRAIL-mediated osteoclast differentiation in RAW macrophages.
TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apop…
ncbi.nlm.nih.gov
Are knockouts of c-Src and TRAF6 osteopetrotic?
Knockouts of c-Src ( 20) and TRAF6 ( 21) are also osteopetrotic, although the bone defects in these animals are not the result of lack of osteoclasts as seen in the p50/p52 NF-κB double knockout, RANK−/−, and the fos−/− mice, but rather are caused by defective osteoclast activity.
A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for …
sciencedirect.com
Feedback
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related ...
Jun 14, 2012 · To understand TRAIL-mediated signal transduction mechanism in osteoclastogenesis, we demonstrated that TRAIL induces osteoclast differentiation via a …
PubMed
https://pubmed.ncbi.nlm.nih.gov
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner
FHL2 inhibits TRAF6-induced NF-kappaB activity in wild-type osteoclast precursors and, in keeping with its role as a suppressor of TRAF6-mediated RANK signaling, TRAF6/RANK …
PubMed
https://pubmed.ncbi.nlm.nih.gov
TRAF6 ubiquitin ligase is essential for RANKL signaling and …
Aug 10, 2007 · Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-kappaB (RANK), plays an essential role in governing the …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
TRAF6 Ubiquitin Ligase is Essential for RANKL Signaling and …
Aug 8, 2007 · Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-κB (RANK), plays an essential role in governing the …

Pagination
- 1
- 2
- 3
- 4
- Next