Dec 25, 2024 · TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are Loss of Function of TGFBR2 in Cancer and TGF-beta receptor signaling activates SMADs.

The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.

TGFBR2 forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta. TGFBR2 directly phosphorylates the PTH1R cytoplasmic domain, which modulates PTH-induced endocytosis of the PTH1R-TGFBR2 complex.

Sep 8, 2024 · Go to complete Gene record for TGFBR2; Go to Variation Viewer for TGFBR2 variants; Summary. The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with …

Apr 29, 2021 · Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex.

HGNC Approved Gene Symbol: TGFBR2. Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38) : 3:30,606,356-30,694,142 (from NCBI) By screening a human hepatoma cell cDNA library with a porcine TGFBR2 cDNA as probe, Lin et al. (1992) isolated a TGFBR2 cDNA encoding a deduced 567-amino acid protein.

Feb 19, 2025 · Loss of smooth muscle cells Tgfbr2 disrupts TGF-beta signaling, acutely alters SMC gene expression, and rapidly results in severe and durable aortopathy. Increased Tgfbr2 expression is associated with pulmonary fibrosis.

Focusing on the receptors in events in and beyond TGF-β signaling, we review the membrane trafficking of TGFBRs, the kinase activity of TGFBR1 and 2, the direct interactions between TGFBR2 and other receptors, and the novel roles of TGFBR3.

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.

Jan 2, 2015 · TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated that loss of Tgfbr2 expression in mammary fibroblasts was linked to tumour initiation and metastasis.