
TGFBR2 Gene - GeneCards | TGFR2 Protein | TGFR2 Antibody
Dec 25, 2024 · TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are Loss of Function of TGFBR2 in Cancer and TGF-beta receptor signaling activates SMADs.
TGFBR2 gene - MedlinePlus
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.
TGFBR2 transforming growth factor beta receptor 2 [ (human)]
TGFBR2 forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta. TGFBR2 directly phosphorylates the PTH1R cytoplasmic domain, which modulates PTH-induced endocytosis of the PTH1R-TGFBR2 complex.
TGFBR2 transforming growth factor beta receptor 2
Sep 8, 2024 · Go to complete Gene record for TGFBR2; Go to Variation Viewer for TGFBR2 variants; Summary. The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with …
Functional similarity between TGF-beta type 2 and type 1
Apr 29, 2021 · Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex.
TRANSFORMING GROWTH FACTOR-BETA RECEPTOR, TYPE II; TGFBR2 …
HGNC Approved Gene Symbol: TGFBR2. Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38) : 3:30,606,356-30,694,142 (from NCBI) By screening a human hepatoma cell cDNA library with a porcine TGFBR2 cDNA as probe, Lin et al. (1992) isolated a TGFBR2 cDNA encoding a deduced 567-amino acid protein.
Tgfbr2 transforming growth factor, beta receptor II [ (house …
Feb 19, 2025 · Loss of smooth muscle cells Tgfbr2 disrupts TGF-beta signaling, acutely alters SMC gene expression, and rapidly results in severe and durable aortopathy. Increased Tgfbr2 expression is associated with pulmonary fibrosis.
TGF-β receptors: In and beyond TGF-β signaling - PubMed
Focusing on the receptors in events in and beyond TGF-β signaling, we review the membrane trafficking of TGFBRs, the kinase activity of TGFBR1 and 2, the direct interactions between TGFBR2 and other receptors, and the novel roles of TGFBR3.
Q62312 - UniProt
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
TGF-beta receptor type-2 expression in cancer-associated ... - PubMed
Jan 2, 2015 · TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated that loss of Tgfbr2 expression in mammary fibroblasts was linked to tumour initiation and metastasis.