TCB-2 - Wikipedia
TCB-2 is a hallucinogen discovered in 2006 by Thomas McLean working in the lab of David Nichols at Purdue University. [1] It is a conformationally-restricted derivative of the …
TCB-2 | 5-HT2A Receptors - Tocris Bioscience
TCB-2 is a high affinity 5-HT 2A receptor agonist (K i values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP 3 accumulation in NIH3T3 cells stably …
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The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and ...
Oct 13, 2009 · Here we provide the first behavioral and neurophysiological profile of TCB-2 in C57BL/6J mice, with direct comparisons to the 5-HT2A/2C agonist (±)-2,5-dimethoxy-4 …
The Serotonin 2A Receptor Agonist TCB-2 Attenuates Heavy …
In this study, we explored the potential of serotonin 2A receptor (5-HT 2A R) agonism to reduce alcohol consumption in male wildtype C57Bl/6J mice and to ameliorate alcohol-induced …
TCB-2, a 5-hydroxytryptamine 2A receptor agonist, disrupts …
Feb 2, 2023 · TCB-2, a 5-hydroxytryptamine 2A receptor agonist, disrupts prepulse inhibition in the ventral pallidum and nucleus accumbens Behav Brain Res . 2023 Feb 2:437:114127. doi: …
TCB-2 [ (7R)-3-bromo-2, 5-dimethoxy-bicyclo [4.2.0]octa-1,3,5 …
Nov 1, 2018 · TCB-2 is a potent 5-HT 2A R ligand with unknown selectivity toward other receptors. The hallucinogenic property of TCB-2 is unknown. TCB-2 behaves as other …
TCB-2, a 5-hydroxytryptamine 2A receptor agonist, disrupts …
Feb 2, 2023 · TCB-2 (10.0 μg/1.0 μl/side), M100907 (5.0 μg/1.0 μl/side) or vehicle (1.0 μl/side) were locally infused into the right lateral ventricular and target brain regions at a rate of 0.5 …
The serotonin 2A receptor agonist TCB-2 attenuates heavy alcohol ...
Mar 2, 2022 · In this study, we explored the potential of serotonin 2A receptor (5-HT 2A R) agonism to reduce alcohol consumption in male wild-type C57Bl/6J mice and to ameliorate …
TCB-2 – Knowledge and References – Taylor & Francis
TCB-2 is a novel psychedelic substance that enhances the consolidation of object memory and acts as an activator of the 5-hydroxytryptamine (5-HT, serotonin) type 2A receptor. It has been …
TCB-2 | CAS:912342-28-0 | Potent, high affinity 5-HT2A agonist
OBJECTIVES: Here we provide the first behavioral and neurophysiological profile of TCB-2 in C57BL/6J mice, with direct comparisons to the 5-HT(2A/2C) agonist (+/-)-2,5-dimethoxy-4 …