Dec 25, 2024 · STK38L (Serine/Threonine Kinase 38 Like) is a Protein Coding gene. Diseases associated with STK38L include Bardet-Biedl Syndrome 18 and Ossification Of The Posterior Longitudinal Ligament Of Spine. Among its related pathways …

High STK38L mRNA expression is associated with decreased overall patient survival in PDACs. STK38L contributes cell invasion and cytokinetic abnormalities of RASSF1A (Ras association (RalGDS/AF-6) domain family member 1)-depleted lung cancer cells by activating YAP [ 70 ].

Feb 8, 2025 · Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. The results demonstrate that NDR2 is a reversible acetylated kinase regulated by SIRT1 and p300/CBP.

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene. [5] [6]

To explore the mechanism underlying myocardial fibrosis, we aimed to determine whether serine/threonine kinase 38 like (STK38L) contributes to the development of myocardial fibrosis by regulating the proliferation and activation of CFs triggered by TGF-β1.

Dec 25, 2024 · STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Among its related pathways are RHOBTB GTPase Cycle and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.

Jun 7, 2022 · Our study identifies a key role of STK38L‐TRIM27‐ULK1 signaling axis in negatively controlling autophagy with relevance established in human breast cancer. While ULK1 is essential for autophagy initiation, the mechanisms controlling its …

Mar 5, 2024 · Clinical resource with information about STK38L, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

May 18, 2015 · Here we demonstrate that Stk38 negatively regulates TLR9-mediated immune responses in macrophages. Stk38 constitutively associates with ubiquitin E3 ligase Smurf1, and facilitates...

Oct 31, 2024 · To explore the mechanism underlying myocardial fibrosis, we aimed to determine whether serine/threonine kinase 38 like (STK38L) contributes to the development of myocardial fibrosis by regulating the proliferation and activation of CFs triggered by TGF-β1.