Apr 28, 2016 · Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy involving the spleen, bone marrow, and frequently the blood. SMZL lymphomagenesis involves antigen and/or superantigen stimulation and molecular deregulation of genes (NOTCH2 and KLF2) involved in the physiological differentiation of spleen marginal zone B cells.

Jul 14, 2023 · Marginal zone lymphoma is a rare type of non-Hodgkin lymphoma. It develops from chronic inflammation or because of a random error in DNA that leads to the creation of abnormal cells. It can be categorized into three subtypes:

In this multi-institutional retrospective cohort study of patients with MZL treated at 10 centers, we evaluated the association between the presence of Ki-67 expression and increased LCs on survival and risk of histologic transformation (HT).

Splenic Marginal Zone Lymphoma (SMZL) - Immunophenotype: With Ki-67, the follicles in SMZL show annular (or target) pattern with proliferating cells in the germinal center and in the peripheral marginal zone.

Aggressive variant of splenic marginal zone lymphoma (AV-SMZL) is a very rare disease that is often associated with TP53 mutations and has a poor prognosis. ... A splenectomy revealed an SMZL pattern with increased numbers of large cells and mitotic cells and a high Ki-67 positivity rate, which led to a diagnosis of AV-SMZL. Although TP53 ...

Nov 2, 2023 · Ki-67 staining was performed on biopsies from 438 MZL patients. Of those, 235 (54%) had low Ki-67 expression (≤10%), and 98 (22%) had Ki-67 >20%, which we determined to be the best prognostic cutoff for high Ki-67 in MZL.

The immunohistochemistry detection revealed that the cells were positive for CD43, Kappa, Ki-67 (30%), CD79a, MUM-1, CD21 (FDC), and CD20 (B cells) but were negative for Cyclin D1, Bcl-6, CD10, Lambda, and CD23, which agrees with the diagnosis of SMZL.

Splenic marginal zone lymphoma (SMZL) is a B-cell neoplasm composed of small lymphocytes that surround and replace the splenic white pulp germinal centers, efface the follicle mantle, and merge with a peripheral (marginal) zone of larger cells, including scattered transformed blasts; both small and larger cells infiltrate the red pulp.

Aims: Splenic marginal zone lymphoma (SMZL) is characterized by a micronodular infiltrate of the splenic white pulp, centred on pre-existing follicles, with a peripheral rim of 'marginal' zone B-cells, always accompanied by a variable degree of red pulp infiltration.

Mar 3, 2018 · Our aim was to investigate the metabolic behavior of SMZL and whether the tumor stage (acc. Ann Arbor) epidemiological (age, gender), histological (Ki-67 index, plasmacytic differentiation), and morphological (splenic diameter maximum) features might be related to 18F-FDG PET/CT results.