Exosomes secreted by adipose mesenchymal stem cells …
Aug 1, 2024 · To investigate the role of SMURF1 in CIH-exposed CCSMCs. In this study, three siRNAs for SMURF1 were successfully constructed and transfected into CCSMCs. All siRNAs …
SMURF1 - Wikipedia
Smad ubiquitination regulatory factor 1 (Smurf1) is part of a gene that encodes a ubiquitin ligase and is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) …
SMURF1: a promising target for colon cancer therapy
Sep 27, 2024 · SMURF1 (Smad ubiquitination regulatory factor 1), a HECT-type E3 ubiquitin ligase, plays pivotal regulatory roles in numerous biological processes, encompassing …
Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated …
Jul 22, 2024 · Here we unveiled an essential role of E3 ligase SMAD ubiquitylation regulatory factor 1 (Smurf1)-mediated phosphoinositide-dependent protein kinase 1 (PDK1) neddylation …
A Smurf1 tale: function and regulation of an ubiquitin ligase in ...
In depth studying of Smurf1 will help us to understand the etiopathological mechanisms of related disorders. Here, we will summarize historical and recent studies on Smurf1, and discuss the …
Exosomes secreted by adipose mesenchymal stem cells ... - PubMed
Results: EXO-circ has the effect of ameliorating ED induced by CIH exposure in rats, the mechanism of which is to promote the expression of the downstream target gene SMURF1 …
Uncovering new insights into the role of the ubiquitin ligase Smurf1 …
In this review, we summarize the role of Smurf1, a protein required for the process of ubiquitination, on the regulation of innate immune signaling and antimicrobial mechanisms, …
CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of …
CKIP-1 is an activator of the Smurf1 ubiquitin ligase acting to promote the ubiquitylation of Smad5 and MEKK2. The mechanisms involved in the recognition and degradation of these substrates …
The E3 ubiquitin ligase SMURF1 regulates cell-fate ... - Nature
Jun 22, 2018 · Smad ubiquitin regulatory factor 1 (SMURF1) is a HECT-type E3 ubiquitin ligase that plays a critical role in vertebrate development by regulating planar cell polarity (PCP) …
Smurf1 Protein Negatively Regulates Interferon-γ Signaling …
May 5, 2012 · Here we identified Smurf1 as a negative regulator for IFN-γ signaling by targeting STAT1 for ubiquitination and proteasomal degradation. Smurf1 interacted with STAT1 through …