
The SLC25 Mitochondrial Carrier Family: Structure and …
Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mitochondrial inner membrane and are crucial for many cellular processes.
The SLC25 Carrier Family: Important Transport Proteins in …
Most carriers are found in the inner membrane of the mitochondrion, but an adenine nucleotide transporter (SLC25A17) has been located in the peroxisome, where it supplies ATP for energy-requiring processes (161).
Physiological and pathological roles of mitochondrial SLC25 carriers
Although their proper function replenishes building blocks needed for metabolic reactions, dysfunctional SLC25 proteins are involved in pathological states. It is the purpose of the present review to cover the current knowledge on the role of SLC25 transporters in health and disease.
The mitochondrial transporter family SLC25 ... - ScienceDirect
Apr 1, 2013 · SLC25 is a large family of nuclear-encoded transporters embedded in the inner mitochondrial membrane and in a few cases other organelle membranes. The members of this superfamily are widespread in eukaryotes and involved in numerous metabolic pathways and …
Tricarboxylate transport protein, mitochondrial - Wikipedia
Tricarboxylate transport protein, mitochondrial, also known as tricarboxylate carrier protein and citrate transport protein (CTP), is a protein that in humans is encoded by the SLC25A1 gene. [5][6][7][8] SLC25A1 belongs to the mitochondrial carrier gene family SLC25. [9][10][11] High levels of the tricarboxylate transport protein are found in th...
The mitochondrial transporter family SLC25: identification
SLC25 is a large family of nuclear-encoded transporters embedded in the inner mitochondrial membrane and in a few cases other organelle membranes. The members of this superfamily are widespread in eukaryotes and involved in numerous metabolic pathways and cell functions.
The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
Nov 28, 2019 · Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mitochondrial inner membrane and are crucial for many cellular processes.
Mitochondrial transporters of the SLC25 family and associated ... - PubMed
To date, 14 inherited diseases (including phenotypes) associated to mitochondrial transporters of the SLC25 family have been well characterized biochemically and genetically. They are rare metabolic disorders caused by mutations in the SLC25 nuclear genes that encode mitochondrial carriers, a superf …
SLC25A51 is a mammalian mitochondrial NAD+ transporter
Sep 9, 2020 · We show that expression of SLC25A51 dictates mitochondrial NAD + levels and uptake capacity in mammalian cells and complements yeast lacking their known mitochondrial NAD + transporters. A nearly...
SLC25A39 is necessary for mitochondrial glutathione import in …
Oct 27, 2021 · Here, using organellar proteomics and metabolomics approaches, we identify SLC25A39, a mitochondrial membrane carrier of unknown function, as a regulator of GSH transport into mitochondria. Loss...