In this review, we summarize our current knowledge of the structure and functions of Sin1, focusing specifically on its protein interaction network and its roles in the mTOR pathway that …

Nov 19, 2019 · In this review, we summarize our current knowledge of the structure and functions of Sin1, focusing specifically on its protein interaction network and its roles in the mTOR …

Jan 31, 2019 · In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell …

Sin1 or MAPKAP1 is a key component of mTORC2 signaling complex which is necessary for AKT phosphorylation at the S473 and T450 sites, and also for AKT downstream signaling as well. A …

Dec 1, 2014 · Mammalian stress-activated protein kinase interacting protein 1 (SIN1), an essential subunit of the mTORC2 complex, maintains the integrity of the complex and substrate …

Oct 6, 2006 · In this study, we identified SIN1/MIP1 as a key TORC2 component and regulator of the Akt pathway that positively controls Akt-Ser473 phosphorylation and activation. These …

Oct 29, 2019 · Composed by Sin1, Rictor, GβL, and mTOR, mTORC2 mainly regulates cell survival and proliferation by phosphorylating hydrophobic motif of AKT (Ser473 site for AKT1) …

Here, we report that SIN1/MIP1 is an essential TORC2/PDK2 subunit. Genetic ab-lation of sin1 abolished Akt-Ser473 phosphory-lation and disrupted rictor-mTOR interaction but maintained …

Nov 5, 2024 · Liu et al reported that the PH domain of Sin1, an essential component of mTORC2, directly binds the PI3K product PtdIns (3,4,5) P3 to promote mTORC2 kinase activation and …

Aug 11, 2015 · We recently showed that the mTORC2 subunit SIN1 is a physiological Akt substrate in 3T3-L1 adipocytes and HEK293 cells, and that phosphorylation of SIN1 T86 by …