
Sin1-mediated mTOR signaling in cell growth, metabolism and …
In this review, we summarize our current knowledge of the structure and functions of Sin1, focusing specifically on its protein interaction network and its roles in the mTOR pathway that …
(PDF) Sin1-mediated mTOR Signaling in Cell Growth, Metabolism …
Nov 19, 2019 · In this review, we summarize our current knowledge of the structure and functions of Sin1, focusing specifically on its protein interaction network and its roles in the mTOR …
Sin1/mTORC2 regulate B cell growth and metabolism by ... - Nature
Jan 31, 2019 · In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell …
Characterization of Sin1 Isoforms Reveals an mTOR-Dependent …
Sin1 or MAPKAP1 is a key component of mTORC2 signaling complex which is necessary for AKT phosphorylation at the S473 and T450 sites, and also for AKT downstream signaling as well. A …
SIN1, a critical component of the mTOR-Rictor complex, is …
Dec 1, 2014 · Mammalian stress-activated protein kinase interacting protein 1 (SIN1), an essential subunit of the mTORC2 complex, maintains the integrity of the complex and substrate …
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and …
Oct 6, 2006 · In this study, we identified SIN1/MIP1 as a key TORC2 component and regulator of the Akt pathway that positively controls Akt-Ser473 phosphorylation and activation. These …
CUL5-SOCS6 complex regulates mTORC2 function by targeting Sin1 …
Oct 29, 2019 · Composed by Sin1, Rictor, GβL, and mTOR, mTORC2 mainly regulates cell survival and proliferation by phosphorylating hydrophobic motif of AKT (Ser473 site for AKT1) …
Here, we report that SIN1/MIP1 is an essential TORC2/PDK2 subunit. Genetic ab-lation of sin1 abolished Akt-Ser473 phosphory-lation and disrupted rictor-mTOR interaction but maintained …
The Sin1 PH domain connects mTORC2 to PI3K - PMC
Nov 5, 2024 · Liu et al reported that the PH domain of Sin1, an essential component of mTORC2, directly binds the PI3K product PtdIns (3,4,5) P3 to promote mTORC2 kinase activation and …
A Positive Feedback Loop between Akt and mTORC2 via SIN1 ...
Aug 11, 2015 · We recently showed that the mTORC2 subunit SIN1 is a physiological Akt substrate in 3T3-L1 adipocytes and HEK293 cells, and that phosphorylation of SIN1 T86 by …