SEC31 is a protein which in yeast promotes the formation of COPII transport vesicles from the Endoplasmic Reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.

Sec31p is a phosphoprotein and treatment of the Sec31p-containing fraction with alkaline phosphatase results in a 50-75% inhibition of transport vesicle formation activity in an ER membrane budding assay.

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Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum. The COPII vesicle coat protein promotes the formation of endoplasmic reticulum- (ER) derived transport vesicles that carry secretory proteins to the Golgi complex in Saccharomyces cerevisiae.

Feb 8, 2025 · We demonstrate through human and Drosophila genetic and in vitro molecular studies, that a severe neurological syndrome is caused by a null mutation in SEC31A, reducing cell viability through enhanced ER-stress response, in line with SEC31A's role in …

Jan 12, 2006 · We present a three-dimensional reconstruction of these Sec13/31 cages at 30 Å resolution using cryo-electron microscopy and single particle analysis. These results reveal a novel cuboctahedron...

Nov 10, 2020 · We identified circSEC31A as a sponge of miR-376a to influence SEC31A expression, thereby regulating NSCLC cell malignant behaviors in vitro and in vivo. The expression pattern of SEC31A was evaluated by the starbase v.3 software in 526 lung adenocarcinoma specimens and 59 normal controls.

Dec 25, 2024 · SEC31A (SEC31 Homolog A, COPII Coat Complex Component) is a Protein Coding gene. Diseases associated with SEC31A include Halperin-Birk Syndrome and Soft Tissue Sarcoma. Among its related pathways are Transport to the Golgi and subsequent modification and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF).

Jan 7, 2010 · Sec23p is a GTPase activating protein (GAP) for the Sar1p GTPase activity (6, 12, and reviewed in 8). Sec24p, Sfb2p, and Sfb3p, are involved in cargo selection (17, 19, 21). Sar1p, the Sec23p-Sec24p heterodimer, and cargo form the prebudding complex.

Protein transport protein SEC31-like; Sec16, Sec23-binding domain; WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; Summaries Gene Snapshot Secretory 31 encodes a protein involved in the innate immune response. [Date last reviewed: 2019-07-11]