Mice with severe combined immunodeficiency (SCIDs) are often used in the research of human disease. Human immune cells are used to develop human lymphoid organs within these immunodeficient mice, and many different types of SCID mouse models have been developed.

SCID mice possess a genetic autosomal recessive mutation designated Prkdc(scid), resulting in severe combined immunodeficiency affecting both B and T lymphocytes.

SCID mice, which virtually lack both T and B lymphocytes and accept xenogeneic cells, have been used during the last 5 years to provide a milieu for lymphocytes isolated from individuals with various autoimmune diseases, or for lymphocytes from mice that have a systemic lupus erythematosus-like syndrome.

SCID mice are deficient in T and B lymphocytes, but retain natural killer (NK) cells and show “leakage” (4). The SCID mutation was then introduced into non-obese diabetic (NOD) mice with NK cell defects to obtain NOD/SCID mice (5), forming the third stage of immunodeficient mice.

Mar 19, 2006 · Immunodeficient mouse models, particularly severe combined immunodeficient (Prkdcscid and Rag1null) mice, are very useful models for immunology, infectious disease, cancer, stem cell biology and other research.

001303 NOD.Cg- Prkdc scid /J Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdc scid , commonly referred to as scid , are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment. Prkdc scid mice accept allogeneic and ...

Mice homozygous for the scid mutation (scid mice) are severely deficient in functional B and T lymphocytes. The mutation appears to impair the recombination of antigen receptor genes and thereby causes an arrest in the early development of B and T lineage-committed cells; other hematopoietic cell ty …

SCID mice, which lack humoral and cellular immunity owing to the absence of mature T or B cells, can support dengue-susceptible human cell line xenografts. SCID mice reconstituted with human peripheral blood lymphocytes (hu-PBL-SCID) have been widely used for studies of HIV pathogenesis and were first evaluated as a dengue model in 1995 [30].

This article focuses on the scid mutation of the mouse (SCID mouse) that causes severe defects in the development of the immune system. The mutation appears to impair the recombination of antigen receptor genes, causing in the SCID mice a lack of functional T and B lymphocytes.

A close-up of white Severe combined immunodeficiency (SCID) mouse held by a human hand. SCID mice are routinely used as model organisms for research into the basic biology of the immune system , cell transplantation strategies, and the effects of …