SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types.

SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is found to cause tumors in humans and animals, but most often persists as a latent infection.

Nov 21, 2005 · DNA tumor viruses such as simian virus 40 (SV40) express dominant acting oncoproteins that exert their effects by associating with key cellular targets and altering the signaling pathways...

SV40 large T antigen (TAg) is a powerful oncoprotein capable of transforming a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRB) and p53 tumor suppressor proteins.

One of its gene products, the large tumour antigen (T-ag), is essential for both viral replication and cell transformation. SV40 T-ag can be considered a dual oncogene protein; it is a composite transforming protein that provides distinct functions at different subcellular locations.

Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively characterized due to its relatively simple genetic organization and the ease with which its genome is manipulated. The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40.

Feb 20, 2009 · Three developments greatly speeded the genetic analysis of SV40, and specifically of large T antigen: DNA sequencing, site-directed mutagenesis, and the ability to insert the SV40 genome into bacterial plasmid vectors.

A cell-free system for replication of SV40 DNA was used to assess the effect of mutations altering either the SV40 origin of DNA replication or the virus-encoded large tumor (T) antigen. Plasmid DNAs containing various portions of the SV40 genome ...

Decades of studies of Simian Virus 40 (SV40), with its double-stranded closed circular DNA genome and its key gene product, the large T-Antigen helicase (T-Ag), provided fundamental early insights into eukaryotic DNA replication (1, 2).

Sep 12, 2023 · In two seminal papers, Kalderon et al. reported a short consensus sequence in the large T antigen of simian virus 40 (SV40) that directs its nuclear localization.