Using an SV40-based model system we provide evidence that duplications of enhancer elements, whether from SV40 itself or from the related BKPyV and JCPyV, increase early gene …

Laboratory-adapted monkey strains of SV40 typically contain two 72-bp enhancer elements (Fig. 4 and 5); these are designated “nonarchetypal” or complex regulatory structures .

SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is …

Feb 1, 1993 · The architecture of the SV40 enhancer has been elucidated by four complementary approaches: (1) saturation mutagenesis in vitro; (2) viral genetic selection in vivo; (3) synthetic …

Jan 1, 1985 · The SV40 early promoter contains at least three spatially distinct elements: (1) two 72-bp repeats comprising the enhancer sequence; (2) three 21-bp repeats, each containing …

We demonstrate that the SV40 enhancer has strong somatic hypermutation targeting activity in several cell types and that AID-induced mutations accumulate in SV40 LT in B cells and …

Feb 1, 1993 · The SV40 enhancer represents a cluster of cell-specific regulatory elements that cooperate with one another in a functional hierarchy. The basic units of enhancer structure, …

The SV40 enhancer is known to be active in a wide variety of tissues and species. It contains a number of sequence motifs that can be bound by protein factors and whose integrity is …

The SV40 enhancer contains three genetically defined elements, called A, B and C, that can functionally compensate for one another. By using short, synthetic DNA oligonucleotides, we …

We have assayed the ability of segments of the simian virus 40 (SV40) 72-base-pair (bp) repeat enhancer region to activate gene expression under the control of the SV40 early promoter and …