Tumor-induced STAT3 plays a central role in regulating both the differentiation and tolerogenic effects of MDSCs. First, STAT3 promotes both expansion and survival of MDSCs through upregulation of Bcl-X L, c-Myc, and Cyclin D1 . In addition, MDSC production depends on STAT3-mediated induction of S100A9 calcium-binding proteins on the cell surface.

Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC). In this study, we characterized CD14+HLA-DR(-/lo) cells sorted from the tumors, draining lymph nodes, and peripheral blood of HNSCC patients. …

Stat3 plays an important role in the development of pancreatic ductal carcinoma (PDAC), and ablation of Stat3 could reduce the incidence of pancreatic intraepithelial neoplasia (PIN) formation in mice [89, 90].

Oct 7, 2021 · Myeloid-derived suppressor cells (MDSCs), characterized by their suppressive effects on immune responses, are important motivators to promote tumor immune escape. MDSCs expand massively...

Mar 30, 2024 · Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial...

STAT3 promotes MDSC accumulation and function through multiple mechanisms. It facilitates the survival of both mouse and human MDSC by up-regulating the proliferation gene cyclin D1 and the antiapoptotic genes Bcl-xl and c-myc ( 98 , 99 ).

Here we studied STAT3 inhibition by Napabucasin as a way to block MDSC accumulation and activity and its potential to treat malignant melanoma. Methods: In vitro generated murine MDSC and primary MDSC from melanoma-bearing mice were used to investigate the effects of Napabucasin on MDSC in vitro.

Apr 1, 2013 · Given the functional significance of STAT3 signaling in myeloid cells in mice, we analyzed intracellular phosphorylated STAT3 (pSTAT3) and ARG1 expression level in the CD14 + HLA-DR –/lo MDSC from HNSCC patients.

Aug 29, 2018 · Our findings suggest that inhibiting STAT3 has potential clinical application for enhancing the efficacy of CAR-T cells in LM through modulation of L-MDSC.

Nov 9, 2010 · It was shown recently that heat-shock protein 72 (Hsp72), which is associated with tumor-derived exosomes, induces suppressive activity of MDSC via activation of Stat3. Hsp72 triggered Stat3 activation in MDSC in a TLR2 and MyD88-dependent manner through autocrine production of IL-6 .