STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator.

Dec 25, 2024 · STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Syndrome 1, Autosomal Dominant, With Recurrent Infections and Autoimmune Disease, Multisystem, Infantile-Onset, 1 .

STAT3 gene mutations are found in approximately one-third of cases of a blood cancer called large granular lymphocytic leukemia (LGL), which is characterized by the accumulation of white blood cells (lymphocytes) that are abnormally large and contain structures called granules.

STAT3 gain-of-function disease (also called STAT3 GOF disease) is a rare genetic disorder of the immune system. STAT3 GOF disease is named after the gene that causes it, STAT3 (signal transducer and activator of transcription 3), and the effect caused by mutations in STAT3—gain-of-function, meaning that the gene’s protein becomes overactive.

Stat3 was first described as a DNA-binding activity from IL-6–stimulated hepatocytes, capable of selectively interacting with an enhancer element in the promoter of acute-phase genes, known as the acute-phase response element (6 – 9).

Dec 3, 2015 · STAT3 is both a transcription activator and an oncogene that is tightly regulated under normal physiological conditions. However, abundant evidence indicates that STAT3 is persistently...

Jan 5, 2025 · Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

Signal transducer and activator of transcription (STAT) proteins represent novel therapeutic targets for the treatment of cancer. In particular, STAT-3 serves critical roles in several cellular processes, including the cell cycle, cell proliferation, cellular apoptosis and tumorigenesis.

Jan 18, 2024 · Focusing on the constitutive activation of STAT3 pathway and the well-established role of STAT3 mutations in T-LGLL, we herein discuss whether the T cell clones occurring in comorbid conditions...