May 2, 2018 · mTOR/S6K1 regulates the SREBP-1c signaling pathway through LXRα in sodium palmitate-induced HepG2 cells, suggesting LXRα might be a potential therapeutic target for NAFLD.

Here we show that Akt-dependent lipogenesis requires mTORC1 activity. Furthermore, nuclear accumulation of the mature form of the sterol responsive element binding protein (SREBP1) and expression of SREBP target genes was blocked by the mTORC1 inhibitor rapamycin.

These results indicate a role for the cAMP/PKA pathway in mediating SREBP-1 and hepatic lipogenesis. It has been shown that the increase in SREBP-1 expression stimulated by insulin can be inhibited by wortmannin and rapamycin, indicating the PI3K-mTORC1 pathway is involved.

Aug 29, 2017 · Hepatic p70 S6 kinase (S6K), the major downstream effector of mTORC1, has been shown to be important for SREBP activation and lipogenesis during fasting and refeeding, and for steatosis in obese...

It is well documented that AMPK phosphorylation inhibits sterol regulatory element-binding protein-1 (SREBP-1), the key transcription factor responsible for fatty acid synthesis, through mammalian target of rapamycin (mTOR) and liver X receptor-α (LXRα) (16).

Sep 24, 2012 · These data reveal a bifurcation in the regulation of SREBP-1c, distal to mTORC1, such that one arm controls SREBP-1c processing and the other regulates gene expression. Still to be uncovered are the mechanisms by which S6K leads to SREBP-1c cleavage.

Apr 6, 2022 · Signaling pathway studies have found that SA affects milk synthesis by upregulating cyclin-dependent kinase 1 (CDK1) to activate PI3K-mTOR-4EBP1/S6K and mTOR-SREBP-1 pathways.

Aug 26, 2011 · The transcription factor sterol regulatory element-binding protein 1c (SREBP1c) plays an important role in the control of fatty acid metabolism in the liver. Evidence suggests that mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contributes to the regulation of SREBP1c expression, but signal …

May 5, 2012 · We created a mouse model of liver-specific knockdown of p70 S6 kinase (S6K) (L-S6K-KD) by systemic delivery of an adeno-associated virus carrying a shRNA for S6K and examined the effects on steatosis and insulin resistance.

Sep 3, 2008 · Here we show that Akt-dependent lipogenesis requires mTORC1 activity. Furthermore, nuclear accumulation of the mature form of the sterol responsive element binding protein (SREBP1) and expression of SREBP target genes was blocked by …