PPARα-dependent Insig2a overexpression inhibits SREBP-1c
Aug 30, 2017 · Peroxisome-proliferator-activated receptor alpha (PPARα) and sterol regulatory element-binding protein (SREBP) play a role in regulating cellular fatty acid and cholesterol …
PPARα-dependent Insig2a overexpression inhibits SREBP-1c
Aug 30, 2017 · Peroxisome-proliferator-activated receptor alpha (PPARα) and sterol regulatory element-binding protein (SREBP) play a role in regulating cellular fatty acid and cholesterol …
A role for PPARalpha in the control of SREBP activity and lipid ...
Jul 15, 2005 · Inclusion of the PPARalpha (peroxisome-proliferator-activated receptor alpha) activator WY 14,643 in the diet of normal mice stimulated the hepatic expression of not only …
Molecular mechanism of PPARα action and its impact on lipid …
Mar 1, 2015 · PPARα can also indirectly modulate SREBP-1c transcription via cross-regulation with the LXR signaling pathway. In mice, PPARα is required for the LXRα-dependent response …
The Effects of Synthetic SREBP-1 and PPAR-γ Decoy …
Sterol regulatory element-binding protein-1 (SREBP-1) and peroxisome proliferator activated receptor-γ (PPAR-γ) are transcription factors that regulate numerous genes involved in lipid …
Molecular mechanism of PPARα action and its ... - Journal of …
PPARα agonists enhance human SREBP-1c transcriptional activity through PPARα interacting with a DR-1 element in the human SREBP-1c promoter. Consistently, PPARα binding to the …
PPARα, PPARγ and SREBP-1 pathways mediated waterborne iron …
Using primary S. hasta hepatocytes, specific pathway inhibitors (GW6471 for PPARα and fatostatin for SREBP-1) and activator (troglitazone for PPARγ) were used to explore the …
SIRT1/SREBPs-mediated regulation of lipid metabolism
Jan 1, 2024 · SIRT1-PPAR-LXR, Fatty, and PUFAs are involved in activation and regulation of transcription of SREBP gene (SREBF) and stability of SREBP mRNA (1). SIRT1-LKB-AMPK …
Regulation of FADS2 transcription by SREBP-1 and PPAR-α
Jan 9, 2017 · Both SREBP-1 and PPAR-α are major regulators of fatty acid metabolic genes including those involved in LC-PUFA synthesis. Two forms of mammalian SREBP-1 have …
Human SREBP1c Expression in Liver Is Directly Regulated by …
We discovered that peroxisome proliferation-activated receptor alpha (PPARα) agonists enhance the activity of the SREBP1c promoter; a DR1 element, at −453 in the human promoter was …