SOS1 is a guanine nucleotide exchange factor (GEF) which interacts with Ras proteins to phosphorylate GDP into GTP, or from an inactive state to an active state to signal cell proliferation.

Dec 25, 2024 · SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with SOS1 include Noonan Syndrome 4 and Fibromatosis, Gingival, 1. Among its related pathways are Downstream signaling of …

The SOS1 gene provides instructions for making a protein that is involved in controlling (regulating) the activation of the RAS/MAPK signaling pathway, which helps control several important cell functions. Learn about this gene and related health conditions.

Jun 29, 2020 · The contributions of wild-type RAS to proliferation and transformation in RAS-mutated cancer cells places renewed interest in upstream signaling molecules, including the RasGEFs SOS1 and 2, as potential therapeutic targets in RAS-mutated cancers.

Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents a unique opportunity for treating RAS-addicted cancers.

Recent exome sequencing analysis has identified SOS1, encoding a guanine nucleotide exchange factor, as significantly mutated in lung adenocarcinomas lacking canonical oncogenic RTK/Ras/Raf pathway mutations.

Oct 26, 2023 · From our structural and functional analyses, we propose a model for how the unique large cytoplasmic domain regulates the Na + /H + exchange activity of SOS1, enhancing our understanding of the...

Sos1 encodes a predicted 1,336-amino acid protein which is 67% identical to the partial Sos2 sequence. Both Sos1 and Sos2 have an overall amino acid identity of 45% with the Drosophila Sos gene product. Northern blots showed that both genes are expressed in a wide variety of tissues and cell lines.

We report on a novel pathogenic mutation in the SOS1 gene and a large clinical spectrum in a Noonan syndrome family with ten genetically confirmed affected individuals. Data indicate dynamic of H-Ras functional cycle as controlled by son of sevenless homolog 1 (Sos).

Findings elucidate the signaling network of SOS1-mediated metastasis in AA patients, from the epigenetic upregulation of SOS1 to the identification of taxifolin as a potential therapeutic strategy against SOS1-driven tumor progression.