SENP1-Sirt3 Signaling Controls Mitochondrial Protein
Aug 22, 2019 · During fasting, SUMO-specific protease SENP1 is accumulated in mitochondria and quickly de-SUMOylates and activates Sirt3. SENP1 deficiency results in hyper …
Dysregulation of SIRT3 SUMOylation Confers AML …
Jul 27, 2022 · Sirtuin 3 (SIRT3) deacetylase is a key regulator for chemoresistance in acute myeloid leukemia (AML) cells due to its capability of modulating mitochondrial metabolism and …
Glucose limitation activates AMPK coupled SENP1-Sirt3 ... - Nature
Jul 16, 2021 · Here, we provide evidence that the SUMO protease SENP1 promotes T cell memory development via Sirt3 deSUMOylation. SENP1-Sirt3 signalling augments the …
Mitochondrial Sirtuin 3: New emerging biological function and ...
SUMOylation is another post-translational modification on SIRT3, which further inhibits its activity. SUMO specific protease SENP1 can de-SUMOylate and activate SIRT3 to promote …
SENP1-SIRT3 axis mediates glycolytic reprogramming to suppress ...
6 days ago · In the SENP1-SIRT3 axis, SENP1 can remove SUMO modifications from SIRT3, thereby increasing SIRT3’s activity. SIRT3, in turn, can remove acetyl modifications from …
Glucose limitation activates AMPK coupled SENP1-Sirt3 ... - PubMed
Jul 16, 2021 · Here, we provide evidence that the SUMO protease SENP1 promotes T cell memory development via Sirt3 deSUMOylation. SENP1-Sirt3 signalling augments the …
SENP1-Sirt3 signaling promotes α-ketoglutarate production …
Apr 12, 2022 · SUMO-specific protease SENP1 enters into mitochondria to activate Sirt3 via de-SUMOylation upon stress (He et al., 2020; Wang et al., 2019). In this study, we demonstrate …
Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3
Jul 9, 2019 · Through systematic profiling studies, we show that human SIRT3 displays class-selective histone de-β-hydroxybutyrylase activities with preference for H3 K4, K9, K18, K23, …
Dysregulation of SIRT3 SUMOylation Confers AML …
Sirtuin 3 (SIRT3) deacetylase is a key regulator for chemoresistance in acute myeloid leukemia (AML) cells due to its capability of modulating mitochondrial metabolism and reactive oxygen …
SUMOylation-Mediated Response to Mitochondrial Stress
Aug 6, 2020 · Upon mitochondrial stress, SUMO specific protease 1 (SENP1) translocates into the mitochondrial matrix and deSUMOylates NAD +-dependent deacetylase sirtuin 3 (SIRT3) …