SIRT3 deacetylates and activates OPA1 to regulate mitochondrial ...
The mitochondrial deacetylase SIRT3 was capable of deacetylating OPA1 and elevating its GTPase activity. Mass spectrometry and mutagenesis analyses indicated that in SIRT3 …
SIRT3 Deacetylates and Activates OPA1 To Regulate …
Acetylation inhibited OPA1 activity, whereas incubation of OPA1 with SIRT3 significantly recovered its GTPase activity in a NAD-dependent manner (Fig. 3A and B). This confirmed …
Sirt3-Mediated Opa1 Deacetylation Protects Against Sepsis
Innovation: Our study revealed, for the first time, the regulation of mitochondrial dynamics and AM polarization by SIRT3-mediated deacetylation of OPA1 in sepsis-induced ALI, which may …
SIRT3 facilitates mitochondrial structural repair and functional ...
Jul 1, 2024 · The findings suggest that SIRT3 has the ability to stimulate the production of OPA1 and boost its functionality by promoting its deacetylation process. Furthermore, therapeutic …
Sirt3-Mediated Opa1 Deacetylation Protects Against Sepsis …
Dec 10, 2024 · Innovation: Our study revealed, for the first time, the regulation of mitochondrial dynamics and AM polarization by SIRT3-mediated deacetylation of OPA1 in sepsis-induced …
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac …
Sirt3 deficiency altered cardiac mitochondrial bioenergetics and caused hyperacetylation of optic atrophy 1 (OPA1), a SIRT3 target. These changes were associated with aberrant alignment of …
Roles of SIRT3 in cardiovascular and neurodegenerative diseases
Feb 1, 2025 · SIRT3 regulates mitochondrial fusion-fission through the function of deacetylation-associated proteins, and the most important proteins in mitochondrial fusion-fission in PD, …
SIRT3: A New Regulator of Cardiovascular Diseases - PMC
SIRT3 overexpression deacetylates and activates OPA1, which regulates mitochondrial dynamics and protects cardiomyocytes from doxorubicin-induced cardiotoxicity [23, 60, 93, 94]. …
SIRT3 mitigates high glucose-induced damage in retinal …
Jan 15, 2025 · SIRT3 protected high glucose-induced endothelial cell damage through the mitochondrial dynamic regulation mediated by OPA1. Oxidative stress in endothelial cells is …
Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein …
A number of mitochondrial proteins and pathways have been found to be involved in the mitochondrial dependent apoptosis mechanism, such as optic atrophy 1 (OPA1), sirtuin 3 …