SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to …
Silent mating type information regulation 2 homolog 1 (SIRT1) plays a critical role in reactive oxygen species-triggered apoptosis in mouse embryonic stem (mES) cells. Here, we …
SIRT1 Regulates PTEN/Akt/FOXO1 Pathway to Trigger ROS-Induced Apoptosis ...
Nov 19, 2010 · In summary, we found that SIRT1 plays a critical role in regulation of the PTEN/Akt/FOXO1 pathway to modulate apoptosis in response to ROS in mES cells. Our data …
SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to …
Nov 17, 2010 · Silent mating type information regulation 2 homolog 1 (SIRT1) plays a critical role in reactive oxygen species-triggered apoptosis in mouse embryonic stem (mES) cells. Here, …
SIRT1 promotes proliferation and inhibits apoptosis of human …
Sep 13, 2012 · In mammalian cells, SIRT1 decreases PTEN acetylation and inactivates the AKT pathway in a SIRT1 deacetylase-dependent manner. However, the function of SIRT1 in glioma …
SIRT1 restoration enhances chondrocyte autophagy in ... - Nature
Apr 15, 2022 · SIRT1 knockdown was found to augment IL-1β-stimulated inflammation and chondrocyte metabolic imbalance. Knockdown of SIRT1 diminished PTEN acetylation and …
Ubiquitin‐specific protease 22 controls melanoma metastasis and ...
Ubiquitin‐specific protease 22 (USP22) stabilizes SIRT1 and activates the PI3K/Akt/mTOR pathway through enhancing SIRT1‐mediated PTEN deacetylation, thereby promoting …
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
Sep 17, 2012 · We report here that transgenic Sirt1 expression is oncogenic in murine thyroid and prostate carcinogenesis initiated by Pten -deficiency. Based on mRNA expression analyses of …
SIRT1-Related Signaling Pathways and Their Association With ...
Feb 21, 2021 · SIRT1 also inhibits the inhibitory effect of PTEN on PI3K by deacetylating PTEN, thereby enhancing PI3K phosphorylation of Akt. The activation of Akt ameliorates BPD by …
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
Aug 22, 2013 · We report here that transgenic Sirt1 expression is oncogenic in murine thyroid and prostate carcinogenesis initiated by Pten-deficiency. Based on mRNA expression analyses of …
SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to …
Nov 17, 2010 · Silent mating type information regulation 2 homolog 1 (SIRT1) plays a critical role in reactive oxygen species-triggered apoptosis in mouse embryonic stem (mES) cells. Here, …
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