PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and ... - Cell …
Nov 2, 2011 · Here we show that both PPARα and Sirt1 are upregulated by pressure overload in the heart. Haploinsufficiency of either PPARα or Sirt1 attenuated pressure overload-induced …
PPARα-Sirt1 complex mediates cardiac hypertrophy and failure …
Nov 2, 2011 · Here we show that both PPARα and Sirt1 are upregulated by pressure overload in the heart. Haploinsufficiency of either PPARα or Sirt1 attenuated pressure overload-induced …
PPARα Association With Sirt1 Suppresses Cardiac Fatty Acid …
Silent information regulator 1 (Sirt1) is a histone deacetylase which interacts with PPARα. To investigate the role of PPARα in the impaired FA utilization observed during HF, genetically …
Sirt1 acts in association with PPARα to protect the heart from ...
May 1, 2011 · Accumulating evidence indicates an important role for Sirt1 in cardiac function, whereas peroxisome proliferator-activated receptor-α (PPARα) is a master controller of …
SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop …
We propose that PPARγ is subject to regulation by acetylation and deacetylation via p300 and SIRT1 in cellular senescence. These results demonstrate a mutual regulation between PPARγ …
SUMOylation of SIRT1 activating PGC-1α/PPARα pathway
Jul 22, 2022 · Here, we found that MHRT improved heart function by attenuating pathological cardiac hypertrophy in vivo and in vitro. MHRT also promoted the SUMOylation of SIRT1 …
Peroxisome Proliferator Activated Receptor-α Association With …
Oct 6, 2015 · Silent information regulator 1 (Sirt1) is a histone deacetylase, which interacts with PPARα. To investigate the role of PPARα in the impaired FA utilization observed during heart …
SUMOylation of SIRT1 activating PGC-1α/PPARα pathway …
Sep 5, 2022 · SIRT1 is the upstream regulatory factor of PGC-1α/PPARα pathway (Chen et al., 2019). Therefore, we explored whether MHRT could activate PGC-1α/PPARα pathway by …
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR …
Jun 2, 2004 · Sirt1 represses PPAR-γ by docking with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors). …
Frontiers | SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia …
Jul 25, 2021 · SIRT1 is a stress-dependent metabolic sensor that can deacetylate some key transcriptional factors in both metabolism dependent and independent metabolic pathways …