SHP-1 and SHP-2 in T cells: two phosphatases functioning at many …
PD-1 has both an ITIM and an ITSM, which have been shown to bind SHP-1 and SHP-2 . In a similar fashion as the other inhibitory receptors, PD-1 acts on proximal TCR signaling by …
Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1
Mar 17, 2020 · PD-1 has one immunoreceptor tyrosine-based inhibitory motif (ITIM) at Y223 and one immunoreceptor tyrosine-based switch motif (ITSM) at Y248. Only ITSM-Y248 is …
- Author: Nikolaos Patsoukis, Jonathan S. Duke-Cohan, Apoorvi Chaudhri, Apoorvi Chaudhri, Halil-Ibrahim Aksoyl...
- Publish Year: 2020
Molecular mechanism of SHP2 activation by PD-1 …
Upon stimulation, PD-1 becomes phosphorylated at its immune receptor tyrosine–based inhibitory motif (ITIM) and immune receptor tyrosine–based …
- Author: M. Marasco, A. Berteotti, J. Weyershaeuser, N. Thorausch, J. Sikorska, J. Krausze, H. J. Brandt, J. ...
- Publish Year: 2020
- Studies of SHP-1 Itim
Phosphatase SHP-1 promotes TLR- and RIG-I-activated …
Apr 6, 2008 · Here we demonstrate that the phosphatase SHP-1 negatively regulated Toll-like receptor–mediated production of proinflammatory cytokines …
- Author: Huazhang An, Jin Hou, Jun Zhou, Wei Zhao, Hongmei Xu, Yuejuan Zheng, Yizhi Yu, Shuxun Liu, Xuetao Ca...
- Publish Year: 2008
SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by …
May 15, 2002 · This phosphatase dead form of SHP-1 has the ability to compete with and block function of both endogenous SHP-1 and SHP-2 on classical KIR due to high-affinity binding …
SHP-1/immunoreceptor tyrosine-based inhibition motif …
Tyrosine phosphorylated Ly-49A recruits SHP-1, but not SHIP, to its ITIM. To further analyse the mechanisms of inhibition mediated by Ly-49A, we introduced mutations into the cytoplasmic …
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A mimotope attached to an ITIM–SHP-1 interaction …
May 19, 2021 · A mimotope attached to an ITIM–SHP-1 interaction inhibitory peptide boosts immune response and efficacy †. Antigen binding to the B-cell receptor initiates a downstream signalling pathway that contains both …
How ITAMs Inhibit Signaling | Science Signaling - AAAS
Apr 19, 2011 · ITAM-mediated inhibition recruits SHP-1 to membrane lipid rafts and diverts activated receptors to an inhibitory intracellular compartment. Immunoreceptor tyrosine-based activation motifs (ITAMs) are used by multiple …
SHP-1- and phosphotyrosine-independent inhibitory signaling by …
May 15, 2002 · Using a retroviral transduction method, we show in human NK cell lines that 1) the single ITIM of 2DL4 efficiently inhibits natural cytotoxicity responses; 2) the phosphorylated …
A mimotope attached to an ITIM-SHP-1 interaction inhibitory
May 19, 2021 · A mimotope attached to an ITIM-SHP-1 interaction inhibitory peptide boosts immune response and efficacy RSC Med Chem . 2021 May 19;12(6):994-999. doi: …
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