In conclusion, our studies demonstrate that mTORC2/Rictor-mediated activation of SGK1/NDRG1 is critical for MesoMT induction and that targeting this pathway could inhibit or even reverse …

Neuronal expression of SGK1 in aged human brain and its nuclear compartmentalization suggest a possible neuroprotective role. FOXO3a and NDRG1 data suggest augmented SGK1 activity …

Here, we describe a surprising role for serum and glucocorticoid kinase-1 (SGK1) in the promotion of energy production when cells are de-tached. Our data demonstrate that SGK1 activation is …

As a serine/threonine kinase, SGK1 catalyzes the phosphorylation of numerous target proteins, including NDRG1, FOXO3a, NEDD4-2, TSC2, ULK1, and β-catenin (Cicenas et al., 2022).

Dec 1, 2024 · The SGK1-dependent phosphorylation of NDRG1 is a marker of mTORC2 activation (Cai et al., 2017). Interestingly, NDRG1 is activated during myelination in …

Dec 12, 2004 · In the present paper, we have identified NDRG2 (n-myc downstream-regulated gene 2) as a protein in muscle extracts that is phosphorylated efficiently by SGK1, but not by …

Aug 3, 2017 · Serum glucocorticoid kinase 1 (Sgk1)-dependent phosphorylation of N-Myc downstream-regulated gene 1 (Ndrg1) is a hallmark of mTORC2 activation in cells. Moreover, …

GR, serum-and glucocorticoid-regulated kinase 1 (Sgk1), and N-myc down regulation gene 1 (NDRG1) were immunolocalized in 98 patients with ESCC who had undergone …

Jan 30, 2013 · Phosphorylation of NDRG1 (an SGK1-specific target) was greater in AD, relative to AC cases (approximately twofold, P = 0.023). Conclusions: Neuronal expression of SGK1 in …

Apr 6, 2014 · We wanted to determine whether SGK1 was activated upon stimulation of T cells by measuring phosphorylation of the SGK1 substrate NDRG1 ('N-myc-downregulated gene 1') at …