In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90 rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70 rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90 rsk in humans, rsk 1-3.

This gene encodes a member of the S6K family of serine/threonine kinases, which phosphorylate several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation.

Jun 15, 2015 · The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as diabetes, cancer and obesity. The activation of the mTOR/S6K axis …

Jul 25, 2022 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been canonically assigned for cell...

The p70 ribosomal S6 kinase (S6K) family is a group of highly conserved kinases in eukaryotes that regulates cell growth, cell proliferation, and stress response via modulating protein synthesis and ribosomal biogenesis.

The ribosomal protein S6 kinase (S6K) family is a key regulator of cell growth and cell size and acts downstream of the PI3K/mTOR pathway, and it has been identified to date to exert crucial functions in many other cellular processes such as metabolism and transcription regulation.

Jun 15, 2015 · The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as diabetes, cancer and obesity. The activation of the mTOR/S6K axis …

Aug 5, 2016 · The S6K proteins are members of the AGC family of serine/threonine kinases and one of the main downstream effectors of the mammalian Target Of Rapamycin (mTOR) protein. In mammals, the S6K family is composed of several proteins encoded by two different genes: RPS6KB1 and RPS6KB2.

Jan 1, 2017 · The ribosomal S6 protein kinases (S6Ks) represent a superfamily of proteins which were originally discovered to phosphorylate ribosomal protein S6. Proteins known as p90 ribosomal S6 kinases (RSKs) have been first identified as able to phosphorylate ribosomal protein S6 (Jones et al. 1988).

Jan 1, 2012 · In the present review we summarize the regulation of S6Ks, their cellular substrates and functions, and their integration within rapidly expanding mTOR (mammalian TOR) signalling networks.