Ribosomal s6 kinase - Wikipedia
In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90 rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70 rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90 rsk in humans, rsk 1-3.
The RSK family of kinases: emerging roles in cellular signalling
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival...
The S6K protein family in health and disease - PubMed
Jun 15, 2015 · The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as diabetes, cancer and obesity. The activation of the mTOR/S6K axis …
Protein Kinase C Phosphorylates Ribosomal Protein S6 Kinase βII …
The ribosomal protein S6 kinase (S6K) belongs to the AGC family of Ser/Thr kinases and is known to be involved in the regulation of protein synthesis and the G 1 /S transition of the cell cycle. There are two forms of S6K, termed S6Kα and …
The S6K protein family in health and disease - ScienceDirect
Jun 15, 2015 · The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as diabetes, cancer and obesity. The activation of the mTOR/S6K axis …
The Role of Ribosomal Protein S6 Kinases in Plant Homeostasis
The p70 ribosomal S6 kinase (S6K) family is a group of highly conserved kinases in eukaryotes that regulates cell growth, cell proliferation, and stress response via modulating protein synthesis and ribosomal biogenesis.
S6Ks isoforms contribute to viability, migration, docetaxel resistance ...
Aug 5, 2016 · The S6K proteins are members of the AGC family of serine/threonine kinases and one of the main downstream effectors of the mammalian Target Of Rapamycin (mTOR) protein. In mammals, the S6K family is composed of several proteins encoded by two different genes: RPS6KB1 and RPS6KB2.
Characterization of the different S6Ks isoforms interacting partners
May 28, 2014 · S6Ks, which phosphorylates ribosomal S6 protein, are effectors of the mTOR pathway. S6K family is composed of two genes (encoding S6K1 and S6K2) and different isoforms from alternative translation initiation (p70-S6K1, p85-S6K1, p54-S6K2, p56S6K2) and alternative splicing (p31-S6K1).
S6 kinase 2 is bound to chromatin-nuclear matrix cellular
The S6K family has two members: S6K1 and S6K2 which bear common as well as distinct features. In an attempt to identify S6K2 unique sequence features compared to S6K1, we applied extensive bioinformatic analysis and motif search approaches.
Ribosomal S6 Kinase - an overview | ScienceDirect Topics
A S6K. Ribosomal S6 kinase (S6K) was the first AGC kinase to be identified as a substrate of mTOR [24]. There are two homologues of S6K in mammals, S6K1 and S6K2, distinguished by divergent sequences in the N- and C-terminal regulatory regions.