Dec 25, 2024 · S100A9 (S100 Calcium Binding Protein A9) is a Protein Coding gene. Diseases associated with S100A9 include Juvenile Rheumatoid Arthritis and Crohn's Disease. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. [5] The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

May 15, 2024 · S100A9 regulates three fundamental mechanisms contributing to lung inflammation in infection. First, it increases the number of myeloid cells in circulation. S100A9 has been shown to induce the differentiation of acute myeloid cells and their growth arrest in human and mouse models of acute myeloid leukemia .

S100A9 was an effective tool to predict the response of tumor patients to immune checkpoint inhibitors (ICIs). (A, B) Differential expression of immune stimulatory genes (A) and immune inhibitory genes (B) between high and low expression groups of S100A9.

Mar 8, 2025 · Intracellular calprotectin (S100A8/A9) facilitates DNA damage responses and promotes apoptosis in head and neck squamous cell carcinoma. Serial measurement of circulating calprotectin as a prognostic biomarker in COVID-19 patients in intensive care setting.

Nov 27, 2023 · As members of the S100 protein subfamily of myeloid-related proteins, S100A8, S100A9 and S100A12 play a crucial role in resisting microbial infection and maintaining immune homeostasis.

May 21, 2020 · We show that S100A9 plays an important role in both the inflammatory and the reparatory immune responses to myocardial infarction. Long-term S100A9 blockade negatively impacts cardiac recovery and counterbalances the beneficial effects of short-term therapy.

Increasing evidence has demonstrated that calprotectin (S100A8/A9) is an endogenous agonist of TLR4 (26). Binding to TLR4 initiates a signaling cascade and regulates inflammation, cell proliferation, differentiation, and tumor development in an NF-κB-dependent manner (8, 26 – 28).

Aug 17, 2024 · Leveraging a wide array of bioinformatics tools and publicly available cancer genomics databases, such as TCGA, we systematically examined the S100A9 gene. Our approach included differential...

Dec 18, 2023 · This study identifies S100A9 as a novel molecular target to treat AML and supports the therapeutic evaluation of tasquinimod in venetoclax-based regimens for AML patients.