Dec 25, 2024 · RPL11 (Ribosomal Protein L11) is a Protein Coding gene. Diseases associated with RPL11 include Diamond-Blackfan Anemia 7 and Diamond-Blackfan Anemia. Among its related pathways are Peptide chain elongation and Nervous system development. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene. [5][6] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.

The RPL11 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Learn about this gene and related health conditions.

Jan 5, 2025 · Title: RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy. Loss of coordinated expression between ribosomal and mitochondrial genes revealed by comprehensive characterization of a large family with a rare Mendelian disorder.

Identification of cancer-associated RPL5 and RPL11 mutations and characterization of their functional significance in vitro and in vivo will be needed to demonstrate conclusively that RPL5 and RPL11 are bona fide tumor suppressors.

RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy. Loss of coordinated expression between ribosomal and mitochondrial genes revealed by comprehensive characterization of a …

Jul 15, 2015 · MDM2 extensively interacts with RPL11 through an acidic domain and two zinc fingers. Formation of the MDM2-RPL11 complex induces substantial conformational changes in both proteins. RPL11, unable to bind MDM2 mutants, fails to induce the activation of p53 in cells.

Diamond–Blackfan anemia is a rare congenital red blood cell dysplasia that develops soon after birth. RPL11 mutations account for approximately 4.8% of human DBA cases with defective hematopoietic phenotypes. However, the mechanisms by which RPL11 regulates hematopoiesis in DBA remain elusive.

Oct 16, 2016 · RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy. Chen J, Lei C, Zhang H, Huang X, Yang Y, Liu J, Jia Y, Shi H, Zhang Y, Zhang J, Du JChen J, et al. BMC Mol Cell Biol, 2023 Mar 3. …

Apr 8, 2022 · Recent discovery of the ribosomal protein (RP) RPL11 interacting with and inhibiting the E3 ubiquitin ligase function of MDM2 established the RP-MDM2-p53 signaling pathway, which is linked to biological events, including ribosomal …