Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation. SIRT1, a class III protein deacetylase, is a crucial cellular survival protein, which is also involved in combatting oxidative stress.

Nov 19, 2010 · SIRT1, an NAD +-dependent histone deacetylase, plays a critical role in endogenous reactive oxygen species (ROS)-triggered apoptosis in mouse ES (mES) cells by blocking nuclear translocation of p53 (Han eta al., Cell Stem Cell, 2008). Here, we investigated a possible role for phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/Akt ...

May 14, 2020 · Studies suggest that SIRT1 is involved in regulating ROS in vitro and in vivo. Modulating the levels of SIRT1 might be a strategy to combat ROS production and could be a novel target for therapy in various pathological conditions.

The AMPK-SIRT1-FOXO pathway affects enzymes responsible for ROS production through direct and indirect mechanisms. Among them, NADPH oxidase is one of the main sources of ROS production. The AMPK-SIRT1-FOXO pathway can reduce ROS generation by decreasing NOX expression or inhibiting its activity .

May 4, 2017 · In bovine retinal capillary endothelial cells (BRECs), Sirt1 overexpression inhibited the increase in mitochondrial reactive oxygen by diminishing NF-κB expression while depletion of Sirt1 via siRNA presented reduced resistance to ROS induced by hyperglycemia stress .

Sep 11, 2013 · SIRT1 (sirtuin-1), an NAD+-dependent protein deacetylase, decreases ROS levels and participates in cell survival under oxidative stress conditions. SIRT1 modulates the transcription factors p53, a tumor suppressor and inducer of apoptosis, and the forkhead O (FOXO) family, both of which play roles for cell survival and cell death.

These phenomena indicate that Sirt1 is upstream of ROS, and ROS bursts result in increased TRAF6 levels. Further, the activation of Sirt1 during the period of ischemia reduced ischemia-induced injury after 72 h of reperfusion in mice with middle cerebral artery occlusion.

Feb 11, 2013 · Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation. SIRT1, a class III protein deacetylase, is a crucial cellular survival protein, which is also involved in combatting oxidative stress.

Nov 17, 2010 · ROS activates PTEN/JNK/FOXO1 and p53 pathways in an SIRT1-dependent manner, whereas DNA-damaging stress activates p53 pathway exclusively, irrespective of SIRT1. p53 functions as a cellular gatekeeper to coordinate diverse cellular responses such as cell cycle arrest, DNA repair, senescence, autophagy, and apoptosis in response to stresses .

May 21, 2024 · The remarkable contribution of our study is the proof that ROS are downregulated by the agonist SIRT1 and that the inhibition of ROS alleviates allodynia in CM rat, as well as reducing central sensitization.