RALA and RALBP1 regulate mitochondrial fission at …
Aug 7, 2011 · Specifically, the mitotic kinase Aurora A phosphorylates Ser 194 of RALA, relocalizing it to the mitochondria, where it concentrates RALBP1 and …
- Author: David F. Kashatus, Kian Huat Lim, Kian Huat Lim, Donita C. Brady, Donita C. Brady, Nicole L.K. Persh...
- Publish Year: 2011
Drp1-Dependent Mitochondrial Fission Plays Critical Roles in ...
Drp1 inhibition by mdivi-1 not only resists IR-induced injury in the heart but also protects other somatic cells from IR injury by blocking the mitochondrial apoptosis pathway [110,111]. …
Obesity causes mitochondrial fragmentation and dysfunction in …
Jan 29, 2024 · Mechanistically, RalA increases fission in adipocytes by reversing the inhibitory Ser637 phosphorylation of the fission protein Drp1, leading to more mitochondrial …
RalBP1 promotes phosphorylation of Drp1. A Immunoblot
A Immunoblot analysis of S616 phosphorylated (p-S616-Drp1), Drp1, RalA, RalBP1 and actin levels in HeLa cells expressing a scramble control, RalA shRNA or RalBP1 shRNA. Graph …
Dynamin-related protein-1 as potential therapeutic target in …
Apr 13, 2017 · Dynamin-related proteins (DRP 1) are crucial for the mitochondrial division, shape, size and for the mitochondrial distribution throughout the neurons, dendrites, cell body to …
- Author: Surinder Singh, Saurabh Sharma
- Estimated Reading Time: 14 mins
- Publish Year: 2017
Mitochondrial Drp1 recognizes and induces excessive mPTP
Nov 5, 2021 · In this study, we performed a series of interaction and colocalization assays and found that, after mitochondrial translocation, Drp1 may promote the excessive opening of the …
RalA and RalBP1 promote mitochondrial localization Drp1. A …
This complex additionally contains the small Ras-like GTPase RALA and its effector RALBP1, which is phosphorylated by aurora A kinase, allowing for RALA-RALBP1 relocation to the …
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle ...
Another proof in cyclin B1/CDK1-mediated mitochondrial dynamics is supported by Ras-related protein Ral-A (RALA) and its effector RalA-binding protein 1 (RALBP1). The mitotic kinase, …
The phosphorylation status of Ser-637 in dynamin-related protein …
Nov 15, 2019 · Recruitment of the GTPase dynamin-related protein 1 (Drp1) to mitochondria is a central step required for mitochondrial fission. Reversible Drp1 phosphorylation has been …
Targeting dynamin-related protein-1 as a potential therapeutic …
Oct 1, 2023 · Dynamin-related protein 1 protein has gained attention due to its interactions with Aβ and hyperphosphorylated Tau in AD. A reduction in Drp1 GTPase activity protects against …
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