
Rad50 ATPase activity is regulated by DNA ends and requires ...
Rad50 ATPase domains dimerize in trans in the presence of ATP (yellow ovals), forming two functional sites as shown. ATP is engaged by Walker A motif K42 from one Rad50 and …
RAD50, an SMC family member with multiple roles in DNA break …
Here we introduce the DNA repair functions of Rad50-containing complexes and compare their architecture with the SMC complexes cohesin and condensin. ATP binding and hydrolysis are …
Mre11 complex links sister chromatids to promote repair of a ... - PNAS
Aug 13, 2018 · Rad50, which resembles “structural maintenance of chromosomes” proteins, is an ATP-binding cassette (ABC)-type ATPase with Walker A and B ATP-binding motifs at its N …
Rad50 - Wikipedia
Human RAD50 deficiency is an autosomal recessive syndrome that has been reported in patients with microcephaly and short stature. Their clinical phenotype resembled Nijmegen Breakage …
RAD50 Mutation - My Cancer Genome
RAD50 Mutation is an inclusion criterion in 16 clinical trials for prostate adenocarcinoma, of which 14 are open and 2 are closed. Of the trials that contain RAD50 Mutation and prostate …
Q92878 - UniProt
RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible …
In silico analysis on the functional and structural impact of Rad50 ...
May 22, 2020 · We identified 103 mostly occurred mutations in the Rad50 protein domains and motifs, which only 42 mutations were classified as most deleterious. These mutations are …
RAD50 Gene - GeneCards | RAD50 Protein | RAD50 Antibody
Dec 25, 2024 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and …
Women who have a pathogenic or likely pathogenic variant (sometimes called a mutation) in the RAD50 gene have a higher-than-average chance to develop breast cancer. The chance to …
Rad50 ATPase activity is regulated by DNA ends and requires ...
Mar 21, 2017 · Rad50 ATPase domains dimerize in trans in the presence of ATP (yellow ovals), forming two functional sites as shown. ATP is engaged by Walker A motif K42 from one Rad50 …