Rad50 ATPase domains dimerize in trans in the presence of ATP (yellow ovals), forming two functional sites as shown. ATP is engaged by Walker A motif K42 from one Rad50 and …

Here we introduce the DNA repair functions of Rad50-containing complexes and compare their architecture with the SMC complexes cohesin and condensin. ATP binding and hydrolysis are …

Aug 13, 2018 · Rad50, which resembles “structural maintenance of chromosomes” proteins, is an ATP-binding cassette (ABC)-type ATPase with Walker A and B ATP-binding motifs at its N …

Human RAD50 deficiency is an autosomal recessive syndrome that has been reported in patients with microcephaly and short stature. Their clinical phenotype resembled Nijmegen Breakage …

RAD50 Mutation is an inclusion criterion in 16 clinical trials for prostate adenocarcinoma, of which 14 are open and 2 are closed. Of the trials that contain RAD50 Mutation and prostate …

RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible …

May 22, 2020 · We identified 103 mostly occurred mutations in the Rad50 protein domains and motifs, which only 42 mutations were classified as most deleterious. These mutations are …

Dec 25, 2024 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and …

Women who have a pathogenic or likely pathogenic variant (sometimes called a mutation) in the RAD50 gene have a higher-than-average chance to develop breast cancer. The chance to …

Mar 21, 2017 · Rad50 ATPase domains dimerize in trans in the presence of ATP (yellow ovals), forming two functional sites as shown. ATP is engaged by Walker A motif K42 from one Rad50 …