In addition, the RACK1/PKC partnership was suggested to be intrinsically linked and PKCs have been shown to regulate RACK1 expression in cardiac myocytes . As well as stabilising PKC …

Sep 20, 2016 · Serum starvation or chemotherapeutic drugs significantly reduced Rack1 level and PKC activation, while promoted cellular apoptosis in both cell lines. Rack1 overexpression …

Jul 1, 2015 · RACK1, originally identified on the basis of its ability to bind to the activated form of protein kinase C (PKC), is highly conserved in yeast, plants, and animals [10]. In humans, …

RACK1 links PKC signaling to the MAP kinase pathway: RACK1 binding to activated PKC leads to the recruitment of JNK into the complex. PKC-mediated phosphorylation of JNK augments …

May 18, 2017 · RACK1, which was first demonstrated as a substrate of PKC β II, functions as a scaffold protein and associates with the 40S small ribosomal subunit. According to previous …

Oct 19, 1999 · Our in vitro data suggest that RACK1 binds selective PH domains, and that PKC regulates this interaction. We propose that, in vivo, RACK1 may colocalize the kinase with its …

Jun 2, 2014 · RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ and was originally identified as the anchoring protein for activated protein kinase C.

Dec 25, 2024 · Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to …

Oct 31, 2002 · RACK1 is one of a group of PKC-interacting proteins collectively called RACKs (Receptors for Activated C-Kinases). Previously, we showed that RACK1 also interacts with …

The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin beta subunit cytoplasmic domains and to members of two …