
RACK1, A multifaceted scaffolding protein: Structure and function
In addition, the RACK1/PKC partnership was suggested to be intrinsically linked and PKCs have been shown to regulate RACK1 expression in cardiac myocytes . As well as stabilising PKC …
RACK1 Function in Cell Motility and Protein Synthesis - PMC
RACK1 links PKC signaling to the MAP kinase pathway: RACK1 binding to activated PKC leads to the recruitment of JNK into the complex. PKC-mediated phosphorylation of JNK augments …
RACK1, scaffolding a heterotrimeric G protein and a MAPK …
Jul 1, 2015 · RACK1, originally identified on the basis of its ability to bind to the activated form of protein kinase C (PKC), is highly conserved in yeast, plants, and animals [10]. In humans, …
RACK1 Gene - GeneCards | RACK1 Protein | RACK1 Antibody
Dec 25, 2024 · Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to …
Structure of a signal transduction regulator, RACK1, from
The receptor for activated C-kinase 1 (RACK1) is a highly conserved WD40 repeat scaffold protein found in a wide range of eukaryotic species from Chlamydymonas to plants and …
RACK1, a Protein Kinase C Anchoring Protein, Coordinates the …
Sep 28, 1999 · Our in vitro data suggest that RACK1 binds selective PH domains, and that PKC regulates this interaction. We propose that, in vivo, RACK1 may colocalize the kinase with its …
The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response …
Our understanding of the enigmatic receptor for activated C-kinase 1 (RACK1) protein has increased dramatically in recent years from its original identification as an anchoring protein for …
RACK1, a versatile hub in cancer | Oncogene - Nature
Jun 2, 2014 · RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ and was originally identified as the anchoring protein for activated protein kinase C.
The WD protein Rack1 mediates protein kinase C and integrin
The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin beta subunit cytoplasmic domains and to members of two …
Increased PKCα activity by Rack1 overexpression is responsible for ...
Sep 20, 2016 · Serum starvation or chemotherapeutic drugs significantly reduced Rack1 level and PKC activation, while promoted cellular apoptosis in both cell lines. Rack1 overexpression …