Sep 15, 2022 · RSL3 sensitivity was restored in HT-1080 ACSL4 KO1 cells by re-expressing the long isoform of ACSL4 (Kuch et al., 2014), confirming that effects on ferroptosis were due to ACSL4 loss specifically (Figures S2E and S2F).

Feb 25, 2025 · In this study, we showed that RSL3 loaded in poly (ethylene glycol)-block-poly (lactide-co-glycolide) (PLGA-PEG) nanoparticles can enhance CAP-induced cell deaths in 4T1 tumor cells.

Feb 24, 2025 · In this study, we present a combined approach of CAP and RSL3 (CAP/RSL3) to enhance the efficacy of cancer therapy treatment (Fig. 1). RSL3 can inactivate GPX4, thereby sensitizing cancer cells to the oxidative stress induced by CAP and further enhancing cancer immunogenic cell death (ICD).

Nov 22, 2018 · Overexpression GPX4 resulted in decreased cell death after RSL3 treatment. Therefore, RSL3 was able to induce ferroptosis on three different CRC cell lines in vitro in a dose- and time-dependent manner, which was due to increased ROS and …

Jul 2, 2024 · In this study, we found that RSL3 inhibited MDS cell proliferation through inducing ROS-dependent apoptosis. RSL3 inhibited Bcl-2 expression and increased caspase 3 and PARP cleavage. RNA-seq...

Sep 15, 2022 · RSL3 sensitivity was restored in HT-1080 ACSL4 KO1 cells by re-expressing the long isoform of ACSL4 (Kuch et al., 2014), confirming that effects on ferroptosis were due to ACSL4 loss specifically (Figures S2 E and S2F).

RAS-selective lethal 3 (RSL3), a well-known inhibitor of glutathione peroxidase 4 (GPX4), could effectively induce oxidative cell death in glioblastoma cells through ferroptosis, and several signaling pathways are involved in this process.

We investigated the effect of RSL3 (a selective ferroptosis inducer) on the viability of three different CRC cells and found RSL3 triggered ferroptotic cell death in a dose- and time-dependent manner, which was due to increased ROS levels and an increase in the cellular labile iron pool.

Ribosomal protein S6 (rpS6) is a critical component of the 40 S ribosomal subunit that mediates translation initiation at the 5′-m 7 GpppG cap of mRNA.

Nov 5, 2024 · In this study, we found that MAT alone could not induce ferroptosis in MLL-r leukemic cells (MOLM-13 and MV4-11), but can synergistically promote ferroptosis with a combination of non-toxic dosage of RSL3 (1μM RLS3 (resulting in 96.17% cell viability) and 0.25 μM MAT for MOLM-13 cells, and 0.125 μM RLS3 (resulting in 95.03% cell viability) and 0...