
NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug ... - PubMed
Mar 1, 2019 · RPS6 inhibition decreases NRF2 expression and restores sensitivity in HER2-amplified gastric cancer in vitro and in vivo. High NRF2 expression in gastric cancer patients …
NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug …
Mar 1, 2019 · We found RPS6 activation and NRF2 to be related to anti-HER2 drug resistance. RPS6 or NRF2 inhibition with siRNA reduced viability and resistance to anti-HER2 drugs. In …
Mechanisms of resistance to trastuzumab in HER2-positive gastric …
Mar 7, 2024 · PI3K/AKT/mTOR/ribosomal protein S6 (RPS6)/nuclear factor erythroid 2-related factor 2 (NRF2) axis. The PI3K/AKT/mTOR pathway is a key pathway for inducing resistance …
Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies
Gambardella and coworkers found that NRF2 amplified the resistance to anti-HER2 drugs through the PI3K/AKT/mTOR/RPS6 pathway, and that ribosomal protein S6 (RPS6) inhibition …
100P - RPS6 through the activation of NRF2 causes resistance to ...
In resistant cells, protein expression underlined the activation of PI3K pathway and of its downstream effector RPS6 protein. Analysing microarray, it was possible to identify, the …
NRF2 activation via PI3K/AKT/mTOR/RPS6 causes ... - Annals of …
Protein expression underlined the activation of PI3K pathway and of its downstream effector RPS6 protein. Data obtained by microarray were analysed, identifying a large number of …
NRF2 activation through RPS6 is related to resistance to both lapatinib and trastuzumab in . HER2. amplified gastric cancer models. Inhibition of RPS6 and NRF2. reduces cell viability . …
Conclusions: NRF2 through the PI3K/AKT/mTOR/RPS6 pathway could be a potential effector of resistance to anti-HER2 drugs in our models. RPS6 inhibition decreases NRF2
[PDF] NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug ...
Nov 30, 2018 · RPS6 inhibition decreases NRF2 expression and restores sensitivity in HER2-amplified gastric cancer in vitro and in vivo. High NRF2 expression in gastric cancer patients …
Inhibition of RPS6 activation by GSK458, a PI3K/TORC1
To address whether RPS6 could be involved in NRF2 increase, a knockdown of RPS6 was performed. Western blot analysis highlighted the decrease of NRF2 expression in LR1OE …