Dec 25, 2024 · RPS14 (Ribosomal Protein S14) is a Protein Coding gene. Diseases associated with RPS14 include Chromosome 5Q Deletion Syndrome and Protein-Deficiency Anemia. Among its related pathways are Peptide chain elongation and Nervous system development.

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene. [5] [6] [7] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.

The RPS14 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Learn about this gene and related health conditions.

Jan 4, 2025 · Fine-structure map of the human ribosomal protein gene RPS14. Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells.

RPS14 and RPS19 have distinct roles in regulating the MDM2-p53 feedback loop in response to ribosomal stress; Loss of RPS14 is associated with 5q-syndrome. Combined loss of miR-145 and RPS14 cooperates to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- …

Feb 15, 2016 · We generated mice with conditional inactivation of Rps14 and demonstrated an erythroid differentiation defect that is dependent on the tumor suppressor protein p53 (encoded by Trp53 in mice) and...

Nov 3, 2024 · Title: Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma. RPS14 promotes the development and progression of glioma via p53 signaling pathway.

We generated mice with conditional inactivation of Rps14 and demonstrated an erythroid differentiation defect that is dependent on the tumor suppressor protein p53 (encoded by Trp53 in mice) and is characterized by apoptosis at the transition from polychromatic to …

Jan 17, 2008 · These data demonstrate that overexpression of RPS14 rescues the erythroid differentiation defect seen in patients with 5q-syndrome, and establishes RPS14 as the likely disease-causing gene.

Objectives: Ribosomal protein S14 (RPS14) plays a key role in erythropoiesis and causes p53 activation in 5q- syndrome. However, the oncogenic potential of RPS14 is not understood in leukemia and high-risk myelodysplastic syndrome (MDS).