PKC is one of the key targets of noncanonical Wnt signaling, particularly in the Wnt/Ca(2+) pathway. Recently, data have implicated components of noncanonical Wnt/Ca(2+) and Wnt/planar cell polarity signaling in directly promoting the invasiveness and malignant progression of diverse forms of human cancer.

May 18, 2019 · Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which are found in familial adenomatosis polyposis and in 80% of sporadic colorectal cancers (CRC), result in constitutive activation of the Wnt/β-catenin pathway and tumor development in the intestine.

XHP treatment downregulated Wnt signaling pathway-related genes, including CCND2, PRKCG, and CCN4. Moreover, XHP effectively inhibited glucose uptake and lactate production, leading to reduced HIF-1α and glycolytic enzymes (GLUT1, HK2, PKM2), suggesting its potential in attenuating the Warburg effect.

Jan 1, 2025 · This is a list of target genes of Wnt/beta-catenin signaling. Suggestions for additions are welcome. There are a separate lists of papers on expression profiling (micro-arrays) on Wnt targets and on target genes that are components of the Wnt pathway (feedback targets).

May 1, 2018 · Gene regulatory network (GRN) analysis demonstrated Mtf2 directly regulates Wnt signaling in erythroblasts, leading to activated canonical Wnt signaling in Mtf2-deficient erythroblasts, while...

High PRKCG improved PAAD and SKCM patients’ survival and reduced KIRC, PCPG, and UVM patients’ survival. Furthermore, elevated PRKCH was associated with better survival in ACC, CESC, CHOL, HNSC, KIRC, LIHC, LUAD, and PRAD, but …

The function of Wnt is most common in embryogenesis and tumorigenesis, but previous literature has only described the carcinogenic effect of Wnt and rarely investigated its predictive ability. Therefore, our study opened up a new horizon for exploring the Wnt pathway.

Dec 25, 2024 · PRKCG (Protein Kinase C Gamma) is a Protein Coding gene. Diseases associated with PRKCG include Spinocerebellar Ataxia 14 and Retinitis Pigmentosa 59. Among its related pathways are Prolactin Signaling and Calmodulin induced events.

Nov 19, 2019 · In this study, we deployed loss and gain of function strategies in N2a cells and primary cortical neurons in vitro, and demonstrated that PKCγ is not only important but necessary for neuronal...

Dec 16, 2013 · Protein kinase C (PKC), a prototypical class of serine/threonine kinases, exemplifies specific signaling molecules that link multiple cellular processes to cancer.