Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and …

Based on plectin’s broad interaction potential, strategic locations, and ample functional repertoire, dysfunctional plectin leads to a variety of disorders and diseases.

Feb 27, 2023 · What is plectin? Plectin is a giant cytoskeletal crosslinker (also known as a cytolinker) protein of more than 4,500 amino acids. It belongs to the plakin family of giant …

Dec 25, 2024 · Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking …

The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities …

Aug 26, 2023 · Herein, we summarized the structure, expression and function of plectin, and mainly focused on recent studies on the functional and physical interactions between plectin …

Jan 29, 2025 · Finally, as increasing evidence suggests that plectin can regulate signalling pathways in response to mechanical cues, we propose a concept in which plectin represents a …

Aug 24, 2024 · Here, we first introduce the molecular structure and function of plectin, and then we summarize the current understanding of the crucial role of plectin in cancer progression.

Mar 5, 2021 · Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell junctions.

Plectin, encoded by PLEC, is a highly conserved and ubiquitously expressed intermediate filament-linking protein with tissue and organelle-specific transcript isoforms that serves as a …