Dec 20, 2023 · PFOS and PFOA can potentially bind with GPx4, GST, CAT, GR, and SOD1. Such interactions can subvert antioxidant enzyme activities. Disruption of redox homeostasis fuels oxidative injuries and cell death.

Jul 15, 2024 · PFOS induced hepatic ferroptosis in vivo and in vitro, as evidenced by the decrease in glutathione peroxidase 4 (GPX4), and the increases in cytosolic iron, acyl-CoA synthetase long-chain family member 4 (ACSL4) and lipid peroxidation.

Nov 15, 2023 · Protein assays revealed that PFOS can suppress the levels of Nrf2, GPX4 and SLC7A11, trigger oxidative damage and promote the occurrence of ferroptosis [Fig. 1 L-M].

Jul 29, 2022 · In our study, we found that PFOS could induce the onset of ferroptosis in HK-2 cells with decreased GPx4 expression and elevated ACSL4 and FTH1 expression, which are hallmarks for the development of ferroptosis. In addition, PFOS-induced ferroptosis in HK-2 cells could be reversed by Fer-1.

Aug 28, 2022 · (4) Results: PFOS was shown to cause a decrease in viability and morphological changes of mitochondria, and well as an increase in lipid droplets. The expression of GPX4, FTH1 and HO-1 was decreased, and that of ACSL4 was increased after exposure to PFOS.

Mar 5, 2025 · PFOS significantly increased reactive oxygen species (ROS) and lipid peroxidation, and depleted glutathione (GSH) in HOK cells. Notably, PFOS decreased glutathione peroxidase 4 (GPX4) expression and elevated Fe 2 + levels, suggesting a potential induction of ferroptosis.

Perfluorooctane sulfonate (PFOS) is a typical persistent organic pollutant and environmental endocrine disruptor that has been shown to be associated with the development of many diseases; it...

Feb 20, 2018 · Glutathione peroxidase 4 (GPX4), an antioxidant enzyme, has biological important functions such as signaling cell death by suppressing peroxidation of membrane phospholipids....

GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation. GPX4 was first discovered in biochemistry laboratories of the University of Padua, where it was described as an enzyme capable of protecting against peroxidation.

Jan 13, 2025 · In addition, PFOA upregulated the levels of malondialdehyde and glutathione/oxidized glutathione and downregulated the expressions of SLC7A11 and GPX4, which refer to typical phenotypes of ferroptosis.