6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene. [5] The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in …

Dec 25, 2024 · PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2) is a Protein Coding gene. Diseases associated with PFKFB2 include Breast Lipoma and Maturity-Onset Diabetes Of The Young, Type 2. Among its related pathways are Glycolysis (REACTOME) and fructose 2,6-bisphosphate biosynthesis.

Feb 16, 2023 · We found that efferocytosis promotes a transient increase in macrophage glycolysis that is dependent on rapid activation of the enzyme...

Mar 27, 2024 · PFKFB2, the cardiac isoform of PFK‐2, is degraded in the heart in the absence of insulin signaling, contributing to diabetes‐induced cardiac metabolic inflexibility. However, previous studies have not examined how the loss of PFKFB2 affects global cardiac metabolism and …

PFK-2/FBPase-2 is a bifunctional enzyme responsible for F-2,6-BP synthesis and degradation. Four isozymes of PFKFB (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified. Alterations in the levels of all PFK-2/FBPase-2 isozymes have been reported in different diseases.

PFKFB2 is a favorable prognostic biomarker for colorectal cancer by suppressing metastasis and tumor glycolysis. Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis. PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells.

Feb 8, 2025 · PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation. PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages.

Dec 25, 2024 · pipeline to measure small molecules that could potentially modulate PFKFB2 and other PFKFB kinase activities. Here we report the recombinant expression, and unexpected serine phosphorylation of PFKFB2 in bacteria, which was subsequently used to optimize an in vitro PFKFB2 kinase activity assay.

Jan 26, 2024 · PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells. A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.

Oct 1, 2013 · Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) enzymes are bi-functional enzymes encoded by four different genes (pfkfb1, pfkfb2, pfkfb3, pfkfb4) in vertebrates. They are involved in the regulation of glycolysis: they catalyze the synthesis and the degradation of F-2,6-BP (fructose-2,6-bisphosphate), the most potent allosteric ...