Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.

Dec 25, 2024 · PDGFRB (Platelet Derived Growth Factor Receptor Beta) is a Protein Coding gene. Diseases associated with PDGFRB include Kosaki Overgrowth Syndrome and Premature Aging Syndrome, Penttinen Type. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

The PDGFRB gene provides instructions for making a protein called platelet-derived growth factor receptor beta (PDGFRβ), which is part of a family of proteins called receptor tyrosine kinases. Learn about this gene and related health conditions.

Platelet-Derived Growth Factor B Is a Key Element in the Pathological Bone Formation of Ankylosing Spondylitis. Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-beta reveals anticancer effect in breast cancer.

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in gastrointestinal stromal tumors (GISTs), inflammatory fibroid polyps and gliomas, and PDGFRB mutations drive myofibroma development. In addition, chromosomal rearrangement of ...

Platelet-derived growth factor receptor β (PDGFRβ) belongs to the family of receptor tyrosine kinases and is widely known for regulating cellular functions like proliferation, angiogenesis, migration, and invasion [54]. TGF-β acts as one of the upstream modulators of PDGFRβ that facilitates EMT induction [55].

Feb 15, 2025 · The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton.

Two highly homologous receptor genes have been cloned: PDGFRA and PDGFRB, which encode the PDGF receptors α and β, respectively. PDGFRα binds to all ligands but PDGF-D, while PDGFRβ binds to PDGF-B and -D only.

The PDGFRB gene encodes platelet-derived growth factor receptor-beta, a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family (see, e.g., PDFGB, 190040).

Feb 15, 2025 · The novel TERF2::PDGFRB fusion gene enhances tumorigenesis via PDGFRB/STAT5 signalling pathways and sensitivity to TKI in ph-like ALL.