31 year old man with pancreatoblastoma (positive) (Clin J Gastroenterol 2018;11:161) 58 year old man with intraductal papillary neoplasm of the biliary tract (atypical) (Diagn Cytopathol 2019;47:922) 60 year old man with paraduodenal pancreatitis found after an initially nondiagnostic biopsy (nondiagnostic) (Case Rep Surg 2020;2020:5021578)

Apr 3, 2024 · Pancreatoblastoma: Primitive pancreatic elements with acinar, ductal and neuroendocrine differentiation Also squamoid corpuscles; more common in children younger than 10 years Positive for beta catenin (80%), neuroendocrine markers and pancreatic enzymes (trypsin, chymotrypsin and lipase) and BCL10

Oct 1, 2021 · Pancreatoblastoma: Pancreatic neoplasm with acinar differentiation: the presence of squamoid nests is diagnostic for pancreatoblastoma Intraductal tubulopapillary neoplasm (ITPN): In cases with intraductal growth BCL10 negative and MUC6 positive

Jun 18, 2021 · SMAD4 tumor suppressor gene is mutated in ~ 55% of pancreatic ductal adenocarcinoma, 25% of extrahepatic cholangiocarcinoma, 34% of ampullary carcinoma and 10 - 20% of colorectal carcinomas, including appendix (Cancer Res 2000;60:2002, PLoS One 2017;9:e115383, Mod Pathol 2003;16:272, Oncogene 1999;18:3098)

Apr 15, 2021 · Poor prognostic factors: high stage, positive margins (particularly radial margin in rectal carcinoma), poor differentiation, signet ring cells, flat or ulcerative gross configuration, tumor budding, tumor perforation, free tumor cells in peritoneal space, lymphovascular invasion, perineurial invasion (Am J Clin Pathol 2003;119:108)

Apr 7, 2022 · Pancreatic mixed neuroendocrine nonneuroendocrine neoplasms (MiNENs) are rare and heterogeneous malignancies characterized by histologically recognizable neuroendocrine (i.e., carcinoma and rarely, a well differentiated neuroendocrine tumor) and exocrine (usually ductal carcinoma, acinar carcinoma or both) components, each composing ≥ 30% of the neoplasm volume (Endocr Pathol 2016;27:284)

Jul 22, 2021 · Considering the WNT / beta catenin alterations along with the common presence of morules, may be regarded as a part of the so called BROCN family tumors (morule forming with biotin rich optically clear nuclei, namely fetal type pulmonary adenocarcinoma, pancreatoblastoma, cribriform morular thyroid carcinomas and some endometrial ...