Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. [5] The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability.

Dec 25, 2024 · PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) is a Protein Coding gene. Diseases associated with PABPC1 include Rift Valley Fever and Dengue Virus . Among its related pathways are Peptide chain elongation and Nervous system development .

The PABPC1 gene, originally isolated and cloned in human melanoma cells by Grange et al. in 1978, is conserved throughout eukaryotes and is located on human chromosome 8 (31, 32). PABPC1 consists of four RNA binding domains (RRM1-4), a linker region and a …

Feb 9, 2025 · PABPC1 regulates proliferation and transformation of gastric cancer cells in vitro and in vivo. PABPC1 knockdown induces apoptosis. PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma.

Jan 5, 2025 · Title: Structural Model of the Human BTG2-PABPC1 Complex by Combining Mutagenesis, NMR Chemical Shift Perturbation Data and Molecular Docking. PABP1 Drives the Selective Translation of Influenza A Virus mRNA.

Jun 20, 2024 · In the H9 nucleus, newly produced (A)-rich circRNAs are bound by PABPC1 and trapped by the nuclear basket protein TPR to prevent their export. Modulating (A)-rich motifs in circRNAs alters their subcellular localization, and introducing (A)-rich circRNAs in H9 cytosols results in mRNA translation suppression.

Mar 5, 2024 · Clinical resource with information about PABPC1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Dec 1, 2022 · In this paper, we review the abnormal expression, functional role, and molecular mechanism of PABPC1 in tumorigenesis and provide directions for further understanding the regulatory role of PABPC1 in tumor cells.

In this study, we report that hnRNPLL specifically associates with cytoplasmic PABPC1 (poly (A)-binding protein 1) in both T cells and plasma cells.

May 14, 2021 · This research aimed to probe the expression characteristics of poly(A)-binding protein cytoplasmic 1 (PABPC1) and its role on the phenotype of ovarian cancer (OC) cells and to further investigate the possible underlying mechanism.