Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major negative regulator for insulin receptor signaling and a novel molecular …

PTP1B is a ubiquitous and abundant intracellular prototypic non-receptor tyrosine phosphatase that is recognized as a major negative regulator of numerous signaling cascades of metabolic …

PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. [6] It has also been …

Jan 6, 2022 · Protein tyrosine phosphatase 1B (PTP1B), one of the main negative regulators of the IR signaling pathway, is broadly expressed in various cells and tissues. PTP1B decreases …

Jun 4, 2022 · PTP1B inhibits the phosphorylation of the insulin receptor and insulin receptor substrate and their downstream PI3K/AKT/GLUT4 signaling, thereby preventing the …

Jun 14, 2023 · Structural and biochemical characterization of the phosphastase and immune checkpoint PTP1B reveals the molecular basis of PTBP1B/JAK interaction and plasticity of …

Mar 1, 2022 · Herein we identify protein tyrosine phosphatase 1B (PTP1B) as an intracellular checkpoint that is upregulated in T cells in tumors. We show that increased PTP1B limits T-cell …

Mar 13, 2014 · Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been suggested as an attractive target to improve insulin sensitivity in different cell types. In the present work, we have...

In this review, we discuss molecular mechanisms by which PTP1B influences metabolic and cardiovascular functions, summarize the latest research on tissue-specific roles of PTP1B, and …

Aug 1, 2020 · PTP1B is an important target for drug developments and linked to many diseases. Different binding sites of protein tyrosine phosphatases and their 3D structure. Different high …