PDBe-KB provides an overview of all the structure information available in the PDB for Human cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)

Dec 25, 2024 · PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha) is a Protein Coding gene. Diseases associated with PRKAR1A include Myxoma, Intracardiac and Acrodysostosis 1 With Or Without Hormone Resistance.

The PRKAR1A gene provides instructions for making one part (subunit) of an enzyme called protein kinase A. This enzyme promotes cell growth and division (proliferation). Protein kinase A is made up of four protein subunits.

Carney complex is a genetic disorder. The condition happens when there is a mutation in the PRKAR1A gene. DNA in this gene tells your body how to make an enzyme that controls how a certain protein behaves. When the PRKAR1A gene mutates, this enzyme can’t control the protein and cells begin to grow in ways they shouldn’t.

Dec 20, 2016 · Protein Kinase cAMP-Dependent Regulatory Type I Alpha (PRKAR1A) is a tissue-specific extinguisher that transduces a signal through phosphorylation of different...

PRKAR1A is a potent tumor suppressor that inhibits the ERK/Snail/E-cadherin pathway in lung adenocarcinoma; t-Darpp phosphorylation at T39 seems to be crucial for t-Darpp-mediated PKA activation and this activation appears to occur through an association with RI and sequestering of RI away from PKAc.

In 2000, we identified inactivating germline mutations of the PRKAR1A gene, encoding the regulatory subunit type 1α (RIα) of protein kinase A (PKA), in the majority of patients with CNC and PPNAD. PRKAR1A mutations causing CNC lead to increased PKA activity.

Dec 1, 2004 · The type 1α regulatory subunit (RIα) of cAMP-dependent protein kinase (PKA) (coded by the PRKAR1A gene) is the main component of type I PKA, which regulates most of the serine-threonine kinase activity catalyzed by the PKA holoenzyme in response to cAMP.

PRKAR1A is a critical component of type I protein kinase A (PKA), the main mediator of cAMP signaling in mammals. PKA is a tetramer consisting of 2 regulatory and 2 catalytic subunits. It is inactive in the absence of cAMP.

The type 1alpha regulatory subunit (RIalpha) of cAMP-dependent protein kinase (PKA) (coded by the PRKAR1A gene) is the main component of type I PKA, which regulates most of the serine-threonine kinase activity catalyzed by the PKA holoenzyme in response to cAMP.