The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a …

RB1 was the first tumor suppressor gene discovered. Over four decades of work have revealed that the Rb protein (pRb) is a master regulator of biological pathways influencing virtually every aspect of intrinsic cell fate including cell growth, ...

These observations suggested that, in vivo, cyclin D-Cdk4/6 complexes are the early-G 1-pRB-hypophosphorylating kinase. To assay for the in vivo requirement of pRB hypophosphorylation, TAT-p16-treated PBLs were assayed for assembly of pRB-E2F4 complexes.

Inactivation of the retinoblastoma protein (pRb) by phosphorylation triggers uncontrolled cell proliferation. Accordingly, activation of cyclin-dependent kinase (CDK)/cyclin complexes or downregulation of CDK inhibitors appears as a common event in human cancer.

The pRB tumor suppressor is traditionally seen as an important regulator of the cell cycle. pRB represses the transcriptional activation of a diverse set of genes by the E2F transcription factors and prevents inappropriate S-phase entry.

Phosphorylation of the retinoblastoma (Rb) gene product, pRb, by members of the cyclin-dependent kinase (cdk) family is an important step in the cell's commitment to undergo mitosis.

We show here that three candidate pRB-inactivating kinases, CDK4-cyclin D1, CDK2-cyclin E, and CDK2-cyclin A, phosphorylate pRB differentially, each on a subset of authentic pRB phosphorylation sites.

Oct 21, 2016 · The retinoblastoma gene product (pRB) is a nuclear phosphoprotein that is thought to play a key role in the negative regulation of cellular proliferation. pRB is phosphorylated in a cell cycle dependent manner, and studies in both actively dividing and differentiated cells suggest that this modification may be essential for cells to progress ...

Dec 1, 1996 · The emerging role of the retinoblastoma protein (pRb) as a major controller of the restriction point has been supported by recent discoveries, including pRb's ability to repress gene transcription by all three RNA polymerases, which suggests a …

Feb 1, 2012 · pRb is a transcriptional cofactor and adaptor protein that functions primarily as a regulator of gene expression, influencing multiple cell processes required for embryonic growth and development.