
Protein kinase C - Wikipedia
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
Protein kinase C in the immune system: from signalling to …
We have discussed examples of PKC isoforms functioning as epigenetic enzymes in neutrophils (PKCδ), macrophages (PKCα, PKCδ), myeloid cells (PKCδ), dendritic cells (PKCζ), B cells (PKCδ) and T cells (PKCδ, PKCε, PKCθ).
Activators and Inhibitors of Protein Kinase C (PKC): Their …
Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or non-classic PKC isozymes (nPKCs; δ, ε, η, and θ), and atypical PKC isozymes (aPKCs; ζ, ι, and λ).
Protein kinase C isoenzymes: a review of their structure, regulation ...
PKC represents a structurally homologous group of proteins of which at present 10 isoforms have been identified unequivocally. The PKC family can be broadly divided into three groups that differ in their cofactor requirements.
Protein Kinase C - an overview | ScienceDirect Topics
PKC is a multifunctional Ser/Thr kinase capable of modulating many cellular processes, including exocytosis and endocytosis of neurotransmitter vesicles, neuronal plasticity, gene expression, regulation of cell growth and cell cycle, ion channels, and receptors.
Protein Kinase C - an overview | ScienceDirect Topics
There are more than 10 subtypes, or isozymes, of PK C. Substrates for protein kinase C include glycogen synthase, the platelet derived growth factor (PDGF) receptor, the epidermal growth factor (EGF) receptor, the insulin receptor, the transferrin receptor, ribosomal protein S6, and Raf.
Protein Kinase C - an overview | ScienceDirect Topics
Protein kinase C (PKC) is a family of structurally related Ser/Thr kinases, which are divided into three families, conventional PKC isozymes (α, βI, βII, γ), atypical PKC isozymes (ζ, ı, λ), and novel PKC isozymes (δ, ε, η, θ).
Signal Transduction Pathways: PKC Family - The Medical …
Jan 31, 2025 · The PKC isoforms have been subdivided into three distinct subfamilies based upon differences in their N-terminal regulatory domain structure. These three subfamilies are referred to as the conventional PKC isoforms (cPKC), the novel PKC isoforms (nPKC), and the atypical PKC isoforms (aPKC).
Protein Kinase C: Perfectly Balanced - PMC - PubMed Central (PMC)
This review describes the tightly controlled mechanisms that ensure PKC activity is perfectly balanced and what happens when these controls are deregulated. PKC isozymes serve as a paradigm for the wisdom of Confucius: “to go beyond is as wrong as to fall short.”
Protein kinase C-α and the regulation of diverse cell responses
Protein kinase C (PKC) comprises a family of lipid-sensitive enzymes that have been involved in a broad range of cellular functions. PKC-α is a member of classical PKC with ubiquitous expression and different cellular localization.