Protein kinase C-associated kinase regulates NF-κB activation ... - PubMed
Suppression of PKK expression by RNA interference inhibits phosphorylation of IKKα and IKKβ as well as activation of NF-κB in human cancer cell lines. Thus, PKK regulates NF-κB activation …
The atypical PKCs in inflammation: NF-κB and beyond - PMC
These studies unveiled, for example, the critical role of PKCζ as a positive regulator of NF-κB through the regulation of RelA but also its inflammatory suppressor activities through the …
NF-κB activation by protein kinase C isoforms and B-cell function
The recent generation of additional KO mice for adapters and kinases implicated in NF-κB activation, including several protein kinase C isoforms, has provided new insights into the roles …
Protein kinase C-associated kinase regulates NF-κB activation …
We propose that PKK may provide a critical link between IKK activation and various upstream signaling cascades, and may represent a potential target for inhibiting abnormal NF-κB …
The PKC-NFκB Signaling Pathway Induces APOBEC3B Expression …
Nov 1, 2015 · Activation of protein kinase C (PKC) by the diacylglycerol (DAG) mimic phorbol-myristic acid (PMA) resulted in specific and dose-responsive increases in APOBEC3B …
NF-κB in biology and targeted therapy: new insights and …
Mar 4, 2024 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling.
PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic
Feb 1, 2018 · Here we identify a new signaling axis of PKCα-LSD1-NF-κB, which is critical for activation and amplification of the inflammatory response. In response to excessive …
From Calcium to NF-κB Signaling Pathways in Neurons - PMC
We demonstrated further that three cellular sensors of the cytosolic Ca 2+ levels, calmodulin, protein kinases C (PKCs), and the p21 ras /phosphatidylinositol 3-kinase (PI3K)/Akt pathway …
PKC ζ at the crossroad of NF-κB and Jak1/Stat6 signaling pathways
Dec 2, 2005 · In this review, we summarize the mechanistic details whereby the aPKC pathway regulates important cellular functions and how this is achieved by the ability of these kinases …
Targeting NF-κB pathway for the therapy of diseases ... - Nature
Sep 21, 2020 · Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers, and NF-κB has been long proposed as the potential …