Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the PRKCD gene. [5] Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. [6] .

Aug 9, 2017 · Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice...

Protein kinase C (PKC)delta was the first new/novel PKC isoform to be identified by the screening of mammalian cDNA libraries, based on the structural homology of its nucleotide sequences with those of classical/conventional PKC isoforms. PKC …

PKC inhibitors and activators are used to understand PKC-mediated intracellular signaling pathways and for the diagnosis and treatment of various PKC-associated diseases, such as cancers, neurological diseases, cardiovascular diseases, and infections.

Dec 25, 2024 · PRKCD (Protein Kinase C Delta) is a Protein Coding gene. Diseases associated with PRKCD include Autoimmune Lymphoproliferative Syndrome, Type Iii and Autosomal Systemic Lupus Erythematosus. Among its related pathways are Prolactin Signaling and Calmodulin induced events.

Protein kinase C delta (PKCδ) has been cloned over 25 years ago and many studies have identified diverse roles and substrates for this member of the family of PKC enzymes in normal and in pathological conditions.

Protein Kinase C Delta (PKC-δ) is a subtype of Protein Kinase C that interacts selectively with other signaling proteins to form signaling complexes, playing a role in various cellular tasks within the cell.

Feb 14, 2022 · PKC-δ is one of the most important and studied targets of the cardiac G protein-coupled receptor signaling pathway. PKC-δ can mediate apoptosis, inflammation, vasoconstriction, and vasodilation of blood vessels, which plays a key role in the regulation of cardiac contractility, ischemic preconditioning, and cardiac structure remodeling.

Aug 19, 2016 · Recently, patients with autosomal recessive mutations in PRKCD encoding protein kinase c delta (PKCδ) have been identified, representing a monogenic prototype for one of the most prominent forms of humoral systemic autoimmune …

Nov 8, 2021 · PKC-delta downregulation in a human neuroblastoma cell line and a PKC-delta knockout mouse cell line reduced BACE1 expression, BACE1-mediated amyloid precursor protein (APP; 104760) processing, and beta-amyloid protein production.