Mar 25, 2023 · Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC …

Another report showed that phosphorylation of PGK1 at serine 203 (S203) correlates with increases in the Warburg effect, hypoxia, expression of oncogenic genes, and cancer …

Feb 26, 2025 · In this study, we demonstrated that multiple metabolic enzymes are activated upon Pim2 upregulation during M1 macrophage polarization. Specifically, Pim2 directly …

Signals (hypoxia, activation of EGFR, and K-Ras/B-Raf mutation) induce ERK-dependent phosphorylation of PGK1 at S203. Phosphorylated PGK1 is transported to mitochondria under …

Here, we find that the S203 phosphorylation recruits PGK1 to endosomal membranes where it acts as a cargo adaptor that recognizes the dileucine sorting signal in EGFR to promote its …

Mechanistically, mitochondrial translocation of PGK1 is mediated by extracellular signal-regulated kinase (ERK) 1/2-dependent S203 phosphorylation, which results in PGK1 isomerization by …

Oct 2, 2019 · These findings highlight the potential use of PGK1 mRNA level, PGK1 promoter hypomethylation, and PGK1 pS203 and PDHK1 pT338 levels as biomarkers for cancer …

StorageStore at -20°C for long term preservation (recommended). Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3 …

5 days ago · Further, we investigated the levels of mitochondrial PGK1 S203 in DUSP4-OE and control cells using an immunofluorescence assay with the MitoTraker staining. As depicted, …

Mar 25, 2023 · Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC …