Mar 25, 2023 · Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC molecular mechanism...

Another report showed that phosphorylation of PGK1 at serine 203 (S203) correlates with increases in the Warburg effect, hypoxia, expression of oncogenic genes, and cancer development.

Here, we find that the S203 phosphorylation recruits PGK1 to endosomal membranes where it acts as a cargo adaptor that recognizes the dileucine sorting signal in EGFR to promote its transport...

Signals (hypoxia, activation of EGFR, and K-Ras/B-Raf mutation) induce ERK-dependent phosphorylation of PGK1 at S203. Phosphorylated PGK1 is transported to mitochondria under the regulation of TOM complex and PIN1.

Feb 26, 2025 · In this study, we demonstrated that multiple metabolic enzymes are activated upon Pim2 upregulation during M1 macrophage polarization. Specifically, Pim2 directly phosphorylates PGK1-S203,...

Oct 2, 2019 · These findings highlight the potential use of PGK1 mRNA level, PGK1 promoter hypomethylation, and PGK1 pS203 and PDHK1 pT338 levels as biomarkers for cancer progression and prognosis, and the promising significance of PGK1 as a …

StorageStore at -20°C for long term preservation (recommended). Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate.

Oct 2, 2019 · Positively correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival (OS) in cancers of the breast, liver, lung, stomach, and esophagus and with advanced TNM stage in breast and esophageal cancers.

5 days ago · Further, we investigated the levels of mitochondrial PGK1 S203 in DUSP4-OE and control cells using an immunofluorescence assay with the MitoTraker staining. As depicted, compared to the control cells, the co-localization of PGK1 S203 and MitoTraker was less prominent in the DUSP4-OE cells (Fig. 4D). This observation suggested that DUSP4 ...

Mar 25, 2023 · Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC molecular mechanism and the development of therapeutic targets.